PMID- 30439307
OWN - NLM
STAT- MEDLINE
DCOM- 20190312
LR  - 20190312
IS  - 2095-4352 (Print)
VI  - 30
IP  - 10
DP  - 2018 Oct
TI  - [Effects of different administration methods of hydrocortisone on blood glucose 
      in patients with septic shock: a Meta-analysis].
PG  - 915-919
LID - 10.3760/cma.j.issn.2095-4352.2018.010.001 [doi]
AB  - OBJECTIVE: To systematically evaluate the effect of different administration 
      methods of hydrocortisone on blood glucose in patients with septic shock. 
      METHODS: The Cochrane Library, PubMed, Web of Science, Embase, CNKI, CBM, 
      Wanfang, and VIP databases were searched from foundation to December 31st, 2017 
      for the randomized controlled trials (RCTs) about hydrocortisone on blood glucose 
      of different drug-deliver ways in patients with septic shock. In addition, the 
      citation retrievals were performed by the literature references. Then the quality 
      evaluation and data extraction was conducted by two researchers independently 
      according to the Cochrane systematic review methods. RevMan 5.3 software was 
      utilized to perform meta-analysis on the influences of the two different 
      administration methods of the continuously pumping hydrocortisone group 
      (experimental group) vs. the intermittently dripping hydrocortisone group 
      (control group) on the mean blood glucose (MBG), largest amplitude of glycemic 
      excursion (LAGE), glucose variability (GV), hyperglycemia time window in patients 
      with septic shock. RESULTS: 1 203 relevant articles were preliminarily searched. 
      Then the duplications were removed, reviews, and non-RCTs and articles evidently 
      not accordant with the inclusion criteria were excluded by titles and abstracts. 
      Eventually a total of 5 well-designed RCTs (404 cases) were incorporated, 
      including 201 cases in the experimental group and 203 cases in the control group. 
      The results of meta-analysis showed that compared with the control group, MBG was 
      significantly decreased in the experimental group [mean difference (MD) = -0.99, 
      95% confidence interval (95%CI) = -1.53 to -0.45, P < 0.05], LAGE was decreased 
      (MD = -5.66, 95%CI = -6.92 to -4.41, P < 0.05), GV was reduced (MD = -0.67, 95%CI 
      = -0.82 to -0.53, P < 0.05), and hyperglycemia time window was shortened (MD = 
      -7.68, 95%CI = -9.03 to -6.33, P < 0.05). The funnel chart revealed that there 
      was publication bias in the MBG, hyperglycemia time window of the articles, and 
      the publication bias was lower in the LAGE and GV. CONCLUSIONS: Compared with 
      intermittent administration method, the continuous pumping hydrocortisone method 
      can stabilize the blood glucose of septic shock patients, shorten the duration of 
      hyperglycemia and reduce the peak value of blood glucose.
FAU - Zhu, Lei
AU  - Zhu L
AD  - Department of Critical Care Unit, the First Hospital of Lanzhou University, 
      Lanzhou 730000, Gansu, China (Zhu L, Dou ZM, Chen QM, Liu J); Department of 
      Endocrinology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, 
      China (Jing GJ); Evidence Based Medicine Center of Lanzhou University, Lanzhou 
      730000, Gansu, China (Zhu L, Li XX, Yang KH, Chen YJ); Key Laboratory of Evidence 
      Based Medicine and Clinical Transformation of Gansu Province, Lanzhou 730000, 
      Gansu, China (Li XX); Public Health of Lanzhou University, Lanzhou 730000, Gansu, 
      China (Li XX); Sun Yat-sen University Zhongshan School of Medicine, Guangzhou 
      510000, Guangdong, China (Liu YS). Corresponding author: Liu Jian, Email: 
      medecinliu@sina.com.
FAU - Li, Xiuxia
AU  - Li X
FAU - Liu, Yishan
AU  - Liu Y
FAU - Yang, Kehu
AU  - Yang K
FAU - Jing, Gaojing
AU  - Jing G
FAU - Chen, Yajing
AU  - Chen Y
FAU - Dou, Zhimin
AU  - Dou Z
FAU - Chen, Qiming
AU  - Chen Q
FAU - Liu, Jian
AU  - Liu J
LA  - chi
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
RN  - 0 (Blood Glucose)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Blood Glucose/*drug effects
MH  - Humans
MH  - Hydrocortisone/*administration & dosage
MH  - Hyperglycemia
MH  - Randomized Controlled Trials as Topic
MH  - Shock, Septic/*drug therapy
EDAT- 2018/11/16 06:00
MHDA- 2019/03/13 06:00
CRDT- 2018/11/16 06:00
PHST- 2018/11/16 06:00 [entrez]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2019/03/13 06:00 [medline]
AID - 10.3760/cma.j.issn.2095-4352.2018.010.001 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 Oct;30(10):915-919. doi: 
      10.3760/cma.j.issn.2095-4352.2018.010.001.