PMID- 3044068
OWN - NLM
STAT- MEDLINE
DCOM- 19880922
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 84
IP  - 2
DP  - 1988 Feb
TI  - Large variations of sucrose in constant carbohydrate diets in type II diabetes.
PG  - 193-200
AB  - Several studies show that sucrose does not aggravate hyperglycemia in type II 
      diabetes mellitus, but sucrose is still restricted in dietary recommendations. 
      Since sucrose in high carbohydrate diets elevates fasting triglyceride levels, 
      the effects of sucrose were evaluated in diets with fixed carbohydrate levels. 
      Eighteen diabetic volunteers receiving no medication were given weight 
      maintenance diets with 50 percent carbohydrate, 35 percent fat, 15 percent 
      protein, and 120 g of sucrose for 10 days as inpatients. They were then randomly 
      assigned diets of similar composition with either 220 g of sucrose (high sucrose 
      diet) or less than 3 g of sucrose daily (complex carbohydrate [CHO] diet) for one 
      additional month. There were no differences in fasting, one-, two-, and 
      three-hour post-lunch serum glucose levels; 24-hour glycosuria; glycohemoglobin 
      levels; fasting and postprandial serum triglyceride levels, or fasting 
      high-density lipoprotein-cholesterol levels. Twelve patients with preexisting 
      higher triglyceridemia had similar trends, but the postprandial triglyceride 
      levels were lower in the high sucrose diet group of this subset (p less than 0.05 
      in the third week). Postprandial serum insulin levels declined in the second week 
      on the complex CHO diet. More than 75-fold difference in sucrose intake with 
      constant carbohydrate and fat did not affect glycemic or triglyceridemic control 
      in type II diabetic patients. The reported high sucrose-carbohydrate-induced rise 
      in fasting triglyceridemia was not present when a diet high in sucrose was given 
      without changing total carbohydrate.
FAU - Abraira, C
AU  - Abraira C
AD  - Medical Service, Hines Veterans Administration Hospital, Illinois 60141.
FAU - Derler, J
AU  - Derler J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 57-50-1 (Sucrose)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/blood/*diet therapy
MH  - *Diet, Diabetic
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Random Allocation
MH  - Sucrose/*administration & dosage
MH  - Triglycerides/blood
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 0002-9343(88)90413-5 [pii]
AID - 10.1016/0002-9343(88)90413-5 [doi]
PST - ppublish
SO  - Am J Med. 1988 Feb;84(2):193-200. doi: 10.1016/0002-9343(88)90413-5.