PMID- 30442388
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20200225
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 294
DP  - 2019 Jan
TI  - The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan 
      in commercially available cannabidiol e-liquids.
PG  - e25-e27
LID - S0379-0738(18)30704-7 [pii]
LID - 10.1016/j.forsciint.2018.10.019 [doi]
AB  - Electronic cigarettes (e-cigarettes) were developed as an alternative method for 
      nicotine delivery and had a significant surge in popularity. E-liquids are 
      formulations used in e-cigarettes, and consist of a ratio of propylene glycol 
      (PG) and vegetable glycerin (VG), a pharmaceutical and/or herbal remedy and, 
      usually, a flavoring agent. Presented is the evaluation of nine cannabidiol (CBD) 
      e-liquids from a single manufacturer for cannabinoids and other psychoactive 
      compounds by Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Gas 
      Chromatography Mass Spectrometry (GC/MS). The analysis of these products resulted 
      in the detection of CBD in all nine produces and the unexpected detections of 
      5-fluoro MDMB-PINACA (5F-ADB) in four of the products and dextromethorphan (DXM) 
      in one of the products. The analysis of these products illustrates the potential 
      quality control issues that can occur in an unregulated industry. CBD products 
      are believed by many users to offer heath benefits, but the detection of a 
      dangerous cannabimimetic, 5F-ADB, and DXM in these products illustrates the need 
      for oversight.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Poklis, Justin L
AU  - Poklis JL
AD  - Virginia Commonwealth University, Department of Pharmacology & Toxicology, 410 
      North 12th Street, Room 754, Box 980613, Richmond, VA 23298-0613, USA. Electronic 
      address: justin.poklis@vcuhealth.org.
FAU - Mulder, Haley A
AU  - Mulder HA
AD  - Virginia Commonwealth University, Department of Forensic Science, 1015 Floyd 
      Avenue, Room 2015, Richmond, VA 23284, USA.
FAU - Peace, Michelle R
AU  - Peace MR
AD  - Virginia Commonwealth University, Department of Forensic Science, 1015 Floyd 
      Avenue, Room 2015, Richmond, VA 23284, USA.
LA  - eng
GR  - I01 BX000150/BX/BLRD VA/United States
GR  - P30 DA033934/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20181101
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Cannabinoids)
RN  - 19GBJ60SN5 (Cannabidiol)
RN  - 7355X3ROTS (Dextromethorphan)
RN  - UN52BPP7RB (5F-ADB cannabinoid)
SB  - IM
MH  - Cannabidiol/*chemistry
MH  - Cannabinoids/*analysis
MH  - Dextromethorphan/*analysis
MH  - *Electronic Nicotine Delivery Systems
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
PMC - PMC6321772
MID - NIHMS1512355
OTO - NOTNLM
OT  - 5-Fluoro MDMB-PINACA
OT  - Cannabidiol
OT  - DART-MS
OT  - Dextromethorphan
OT  - Electronic cigarettes
OT  - Electronic liquids
EDAT- 2018/11/18 06:00
MHDA- 2019/03/05 06:00
PMCR- 2020/01/01
CRDT- 2018/11/17 06:00
PHST- 2018/09/03 00:00 [received]
PHST- 2018/10/24 00:00 [revised]
PHST- 2018/10/26 00:00 [accepted]
PHST- 2018/11/18 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2018/11/17 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - S0379-0738(18)30704-7 [pii]
AID - 10.1016/j.forsciint.2018.10.019 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2019 Jan;294:e25-e27. doi: 10.1016/j.forsciint.2018.10.019. 
      Epub 2018 Nov 1.