PMID- 30442605 OWN - NLM STAT- MEDLINE DCOM- 20200101 LR - 20231006 IS - 1525-8955 (Electronic) IS - 0885-3010 (Print) IS - 0885-3010 (Linking) VI - 66 IP - 1 DP - 2019 Jan TI - An FPGA-Based Backend System for Intravascular Photoacoustic and Ultrasound Imaging. PG - 45-56 LID - 10.1109/TUFFC.2018.2881409 [doi] AB - The integration of intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging produces an imaging modality with high sensitivity and specificity which is particularly needed in interventional cardiology. Conventional side-looking IVUS imaging with a single-element ultrasound (US) transducer lacks forward-viewing capability, which limits the application of this imaging mode in intravascular intervention guidance, Doppler-based flow measurement, and visualization of nearly, or totally blocked arteries. For both side-looking and forward-looking imaging, the necessity to mechanically scan the US transducer limits the imaging frame rate, and therefore, array-based solutions are desired. In this paper, we present a low-cost, compact, high-speed, and programmable imaging system based on a field-programmable gate array suitable for dual-mode forward-looking IVUS/IVPA imaging. The system has 16 US transmit and receive channels and functions in multiple modes including interleaved photoacoustic (PA) and US imaging, hardware-based high-frame-rate US imaging, software-driven US imaging, and velocity measurement. The system is implemented in the register-transfer level, and the central system controller is implemented as a finite-state machine. The system was tested with a capacitive micromachined ultrasonic transducer array. A 170-frames-per-second (FPS) US imaging frame rate is achieved in the hardware-based high-frame-rate US imaging mode while the interleaved PA and US imaging mode operates at a 60-FPS US and a laser-limited 20-FPS PA imaging frame rate. The performance of the system benefits from the flexibility and efficiency provided by the low-level implementation. The resulting system provides a convenient backend platform for research and clinical IVPA and IVUS imaging. FAU - Wu, Xun AU - Wu X FAU - Sanders, Jean L AU - Sanders JL FAU - Zhang, Xiao AU - Zhang X FAU - Yamaner, Feysel Yalcin AU - Yamaner FY FAU - Oralkan, Omer AU - Oralkan O LA - eng GR - R01 HL117740/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20181114 PL - United States TA - IEEE Trans Ultrason Ferroelectr Freq Control JT - IEEE transactions on ultrasonics, ferroelectrics, and frequency control JID - 9882735 SB - IM MH - Algorithms MH - Equipment Design MH - Image Processing, Computer-Assisted/*methods MH - Phantoms, Imaging MH - Photoacoustic Techniques/instrumentation/*methods MH - Transducers MH - Ultrasonography, Interventional/instrumentation/*methods PMC - PMC6384193 MID - NIHMS1519309 EDAT- 2018/11/18 06:00 MHDA- 2020/01/02 06:00 PMCR- 2020/01/01 CRDT- 2018/11/17 06:00 PHST- 2018/11/18 06:00 [pubmed] PHST- 2020/01/02 06:00 [medline] PHST- 2018/11/17 06:00 [entrez] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.1109/TUFFC.2018.2881409 [doi] PST - ppublish SO - IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Jan;66(1):45-56. doi: 10.1109/TUFFC.2018.2881409. Epub 2018 Nov 14.