PMID- 30443202
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 12
DP  - 2018
TI  - Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of 
      Septohippocampal Cholinergic Structure and Function.
PG  - 773
LID - 10.3389/fnins.2018.00773 [doi]
LID - 773
AB  - Exercise has been shown to improve or rescue cognitive functioning in both humans 
      and rodents, and the augmented actions of neurotrophins within the hippocampus 
      and associated regions play a significant role in the improved neural plasticity. 
      The septohippocampal circuit is modified by exercise. Beyond an enhancement of 
      spatial working memory and a rescue of hippocampal activity-dependent 
      acetylcholine (ACh) efflux, the re-emergence of the cholinergic/nestin neuronal 
      phenotype within the medial septum/diagonal band (MS/dB) is observed following 
      exercise (Hall and Savage, 2016). To determine which neurotrophin, brain-derived 
      neurotrophic factor (BDNF) or nerve growth factor (NGF), is critical for 
      exercise-induced cholinergic improvements, control and amnestic rats had either 
      NGF or BDNF sequestered by TrkA-IgG or TrkB-IgG coated microbeads placed within 
      the dorsal hippocampus. Hippocampal ACh release within the hippocampus during 
      spontaneous alternation was measured and MS/dB cholinergic neuronal phenotypes 
      were assessed. Sequestering NGF, but not BDNF, abolished the exercise-induced 
      recovery of spatial working memory and ACh efflux. Furthermore, the re-emergence 
      of the cholinergic/nestin neuronal phenotype within the MS/dB following exercise 
      was also selectively dependent on the actions of NGF. Thus, exercise-induced 
      enhancement of NGF within the septohippocampal pathway represents a key avenue 
      for aiding failing septo-hippocampal functioning and therefore has significant 
      potential for the recovery of memory and cognition in several neurological 
      disorders.
FAU - Hall, Joseph M
AU  - Hall JM
AD  - Behavioral Neuroscience Program, Department of Psychology, Binghamton University, 
      Binghamton, NY, United States.
FAU - Gomez-Pinilla, Fernando
AU  - Gomez-Pinilla F
AD  - Department of Integrative Biology and Physiology, University of California, Los 
      Angeles, Los Angeles, CA, United States.
FAU - Savage, Lisa M
AU  - Savage LM
AD  - Behavioral Neuroscience Program, Department of Psychology, Binghamton University, 
      Binghamton, NY, United States.
LA  - eng
GR  - R01 AA021775/AA/NIAAA NIH HHS/United States
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - R21 NS085502/NS/NINDS NIH HHS/United States
GR  - T32 AA025606/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20181101
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6222249
OTO - NOTNLM
OT  - BDNF
OT  - NGF
OT  - acetylcholine
OT  - basal forebrain
OT  - exercise
OT  - hippocampus
OT  - nestin
EDAT- 2018/11/18 06:00
MHDA- 2018/11/18 06:01
PMCR- 2018/01/01
CRDT- 2018/11/17 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2018/11/17 06:00 [entrez]
PHST- 2018/11/18 06:00 [pubmed]
PHST- 2018/11/18 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2018.00773 [doi]
PST - epublish
SO  - Front Neurosci. 2018 Nov 1;12:773. doi: 10.3389/fnins.2018.00773. eCollection 
      2018.