PMID- 30443217
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Black Garlic Improves Heart Function in Patients With Coronary Heart Disease by 
      Improving Circulating Antioxidant Levels.
PG  - 1435
LID - 10.3389/fphys.2018.01435 [doi]
LID - 1435
AB  - Background: Black garlic (BG) has many health-promoting properties. Objectives: 
      We aimed to explore the clinical effects of BG on chronic heart failure (CHF) in 
      patients with coronary heart disease (CHD). Design: The main components of BG 
      were measured by gas chromatography-mass spectrometry (GC-MS) and its antioxidant 
      properties were determined by the clearance rate of free radicals. One hundred 
      twenty CHF patients caused by CHD were randomly and evenly assigned into BG group 
      and placebo group (CG). The duration of treatment was 6 months. Cardiac function 
      was measured according to the New York Heart Association (NYHA) functional 
      classification system. The following parameters were measured, including walking 
      distance, BNP precursor N-terminal (Nt-proBNP), left-ventricular ejection 
      fraction (LVEF) value, and the scores of quality of life (QOL). The circulating 
      antioxidant levels were compared between two groups. Results: There are 27 main 
      compounds in BG with strong antioxidant properties. BG treatment improved cardiac 
      function when compared with controls (P < 0.05). The QOL scores and LVEF values 
      were higher in the BG group than in the CG group while the concentration of 
      Nt-proBNP was lower in the BG group than in the CG group (P < 0.05). Circulating 
      antioxidant levels were higher in the BG group than in the CG group. Antioxidant 
      levels had positive relation with QOL and LVEF values, and negative relation with 
      Nt-proBNP values. Conclusion: BG improves the QOL, Nt-proBNP, and LVEF in CHF 
      patient with CHD by increasing antioxidant levels.
FAU - Liu, Jingbo
AU  - Liu J
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Zhang, Guangwei
AU  - Zhang G
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Cong, Xiaoqiang
AU  - Cong X
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Wen, Chengfei
AU  - Wen C
AD  - Department of Cardiovascular, The First Hospital of Jilin University, Changchun, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20181101
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6221913
OTO - NOTNLM
OT  - black garlic
OT  - congestive heart failure
OT  - coronary heart disease
OT  - left-ventricular ejection fraction
OT  - quality of life
EDAT- 2018/11/18 06:00
MHDA- 2018/11/18 06:01
PMCR- 2018/11/01
CRDT- 2018/11/17 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2018/09/20 00:00 [accepted]
PHST- 2018/11/17 06:00 [entrez]
PHST- 2018/11/18 06:00 [pubmed]
PHST- 2018/11/18 06:01 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01435 [doi]
PST - epublish
SO  - Front Physiol. 2018 Nov 1;9:1435. doi: 10.3389/fphys.2018.01435. eCollection 
      2018.