PMID- 3044523
OWN - NLM
STAT- MEDLINE
DCOM- 19881013
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 20
IP  - 6
DP  - 1988 Jun
TI  - Cardiovascular input to hypothalamic neurosecretory neurons.
PG  - 771-7
AB  - In vivo extracellular recordings from rat supraoptic and paraventricular 
      magnocellular neurosecretory cells (MNCs) indicate that putative 
      vasopressin-secreting MNCs may be identified by an abrupt and brief cessation in 
      firing consequent to a transient drug-induced rise in arterial pressure 
      sufficient to activate arterial baroreceptors. In the diagonal band of Broca 
      (DBB), a population of neurons projecting towards the supraoptic nucleus are 
      activated during this drug-induced hypertension. Electrical stimulation in DBB 
      selectively depresses supraoptic vasopressin-secreting MNCs. Intracellular 
      recordings in perfused hypothalamic explants confirm a DBB-evoked 
      bicuculline-sensitive and chloride-dependent postsynaptic inhibition, similar to 
      that associated with the application of gamma-aminobutyric acid (GABA) in 
      approximately half of supraoptic MNCs. Since bicuculline also selectively blocks 
      baroreceptor-induced inhibition in supraoptic MNCs, it is proposed that the 
      depressant baroreflex input to vasopressin-secreting MNCs involves a population 
      of DBB neurons and GABAergic interneurons located close to MNCs. An excitatory 
      and selective input to vasopressin-secreting MNCs follows chemoreceptor 
      activation, possibly mediated by the A1 noradrenergic cell group in the 
      ventrolateral medulla. Another excitatory input to both vasopressin- and 
      oxytocin-secreting MNCs is triggered by circulating angiotensin II and appears to 
      be relayed centrally through an angiotensinergic projection from the subfornical 
      organ.
FAU - Renaud, L P
AU  - Renaud LP
AD  - Neurosciences Unit, Montreal General Hospital, Quebec Canada.
FAU - Jhamandas, J H
AU  - Jhamandas JH
FAU - Buijs, R
AU  - Buijs R
FAU - Raby, W
AU  - Raby W
FAU - Randle, J C
AU  - Randle JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 11000-17-2 (Vasopressins)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - *Cardiovascular Physiological Phenomena
MH  - Chemoreceptor Cells/*physiology
MH  - Hypothalamus/metabolism/*physiology
MH  - Oxytocin/metabolism
MH  - Pressoreceptors/*physiology
MH  - Rats
MH  - Vasopressins/metabolism
RF  - 53
EDAT- 1988/06/01 00:00
MHDA- 1988/06/01 00:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 1988/06/01 00:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
AID - 0361-9230(88)90090-1 [pii]
AID - 10.1016/0361-9230(88)90090-1 [doi]
PST - ppublish
SO  - Brain Res Bull. 1988 Jun;20(6):771-7. doi: 10.1016/0361-9230(88)90090-1.