PMID- 30448130
OWN - NLM
STAT- MEDLINE
DCOM- 20200324
LR  - 20200801
IS  - 1876-7591 (Electronic)
IS  - 1936-878X (Print)
IS  - 1876-7591 (Linking)
VI  - 12
IP  - 8 Pt 2
DP  - 2019 Aug
TI  - Comparing CMR Mapping Methods and Myocardial Patterns Toward Heart Failure 
      Outcomes in Nonischemic Dilated Cardiomyopathy.
PG  - 1659-1669
LID - S1936-878X(18)30749-6 [pii]
LID - 10.1016/j.jcmg.2018.08.021 [doi]
AB  - OBJECTIVES: In patients with nonischemic dilated cardiomyopathy (NIDCM), native 
      T1, partition coefficient (lambda(Gd)), and extracellular volume fraction (ECV) 
      mapping may offer prognostic values beyond late gadolinium enhancement (LGE), by 
      scaling the range of myocardial changes. BACKGROUND: In patients with NIDCM, LGE 
      is seen in 30% of patients and it indicates adverse prognosis. METHODS: The study 
      mapped 6 anatomical locations using all 4 cardiac magnetic resonance (CMR) 
      tissue-characterizing methods and associated with outcome. The authors performed 
      T1 mapping of the myocardium and the blood pool, before and serially after 
      contrast injection, using a Look-Locker cine gradient-echo technique to obtain T1 
      and the corresponding reciprocal R1 values. lambda(Gd) values were derived from the 
      slopes of the least-squares regression lines for myocardial versus blood R1, then 
      adjusted to serum hematocrit to yield ECV. RESULTS: Consecutive 240 NIDCM 
      patients (49 +/- 16 years of age; 38% women) underwent CMR for cardiac function, 
      LGE, native T1, lambda(Gd), and ECV. After a median of 3.8 years, 36 (15%) experienced 
      major adverse cardiac events (MACE), including 22 heart failure hospitalizations 
      and 14 deaths. Nonischemic LGE was detected in 34%, whereas ECV was elevated (>/=1 
      location) in 58%. Comparing the 4 methods, mean ECV and lambda(Gd) both demonstrated 
      strong association with MACE (both p < 0.001). In contrast to native T1 and LGE, 
      ECV values from all 6 locations were associated with MACE and death, with the 
      anteroseptum being the most significant (p < 0.0001). The number of abnormal ECV 
      locations correlated linearly with annual MACE rates (p = 0.0003). Mean ECV was 
      the only predictor to enter a prognostic model that contained age, sex, New York 
      Heart Association functional class, and left ventricular ejection fraction. For 
      every 10% increase, mean ECV portended to a 2.8-fold adjusted increase risk to 
      MACE (p < 0.001). CONCLUSIONS: In this study of patients with NIDCM, mapping the 
      myocardial extent of abnormality using ECV offers prognostication toward heart 
      failure outcomes incremental to LGE or native T1 mapping.
CI  - Copyright (c) 2019 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Vita, Tomas
AU  - Vita T
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Grani, Christoph
AU  - Grani C
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Abbasi, Siddique A
AU  - Abbasi SA
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Neilan, Tomas G
AU  - Neilan TG
AD  - Cardiac MR PET CT Program and Division of Cardiology, Department of Medicine, 
      Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Rowin, Ethan
AU  - Rowin E
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Kaneko, Kyoichi
AU  - Kaneko K
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Coelho-Filho, Otavio
AU  - Coelho-Filho O
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Watanabe, Eri
AU  - Watanabe E
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Mongeon, Francois-Pierre
AU  - Mongeon FP
AD  - Department of Medicine, Montreal Heart Institute, Universite de Montreal, 
      Montreal, Quebec, Canada.
FAU - Farhad, Hoshang
AU  - Farhad H
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Rassi, Carlos Henrique
AU  - Rassi CH
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Choi, Yuna L
AU  - Choi YL
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Cheng, Kathleen
AU  - Cheng K
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Givertz, Michael M
AU  - Givertz MM
AD  - Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts.
FAU - Blankstein, Ron
AU  - Blankstein R
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular 
      Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical 
      School, Boston, Massachusetts.
FAU - Steigner, Michael
AU  - Steigner M
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Aghayev, Ayaz
AU  - Aghayev A
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Jerosch-Herold, Michael
AU  - Jerosch-Herold M
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts.
FAU - Kwong, Raymond Y
AU  - Kwong RY
AD  - Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular 
      Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical 
      School, Boston, Massachusetts. Electronic address: rykwong@bwh.harvard.edu.
LA  - eng
GR  - T32 HL094301/HL/NHLBI NIH HHS/United States
GR  - R01 HL137562/HL/NHLBI NIH HHS/United States
GR  - R01 HL090634/HL/NHLBI NIH HHS/United States
GR  - R01 HL091157/HL/NHLBI NIH HHS/United States
GR  - UH2 TR000901/TR/NCATS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181115
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2019 Aug;12(8 Pt 2):1670-1672. PMID: 30448140
CIN - JACC Cardiovasc Imaging. 2019 Dec;12(12):2586-2587. PMID: 31806186
CIN - JACC Cardiovasc Imaging. 2019 Dec;12(12):2587-2588. PMID: 31806187
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/complications/*diagnostic 
      imaging/pathology/physiopathology
MH  - Contrast Media/*administration & dosage
MH  - Disease Progression
MH  - Female
MH  - Gadolinium DTPA/*administration & dosage
MH  - Heart Failure/diagnosis/*etiology/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC6506397
MID - NIHMS1512036
OTO - NOTNLM
OT  - ECV
OT  - NIDCM
OT  - dilated cardiomyopathy
OT  - native T1
OT  - partition coefficient
EDAT- 2018/11/19 06:00
MHDA- 2020/03/25 06:00
PMCR- 2020/08/01
CRDT- 2018/11/19 06:00
PHST- 2018/06/25 00:00 [received]
PHST- 2018/08/13 00:00 [revised]
PHST- 2018/08/15 00:00 [accepted]
PHST- 2018/11/19 06:00 [pubmed]
PHST- 2020/03/25 06:00 [medline]
PHST- 2018/11/19 06:00 [entrez]
PHST- 2020/08/01 00:00 [pmc-release]
AID - S1936-878X(18)30749-6 [pii]
AID - 10.1016/j.jcmg.2018.08.021 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2019 Aug;12(8 Pt 2):1659-1669. doi: 
      10.1016/j.jcmg.2018.08.021. Epub 2018 Nov 15.