PMID- 30448180
OWN - NLM
STAT- MEDLINE
DCOM- 20200508
LR  - 20200508
IS  - 1476-5411 (Electronic)
IS  - 1367-0484 (Linking)
VI  - 42
IP  - 2
DP  - 2019 Apr
TI  - Light disturbance analysis in the controlled randomized clinical trial MiSight((R)) 
      Assessment Study Spain (MASS).
PG  - 200-205
LID - S1367-0484(18)30381-3 [pii]
LID - 10.1016/j.clae.2018.11.006 [doi]
AB  - PURPOSE: To evaluate the perception of light disturbances (LD) in children 
      wearing Dual Focus (DF) MiSight(R) contact lenses (CLs) for myopia control compared 
      with children wearing single vision spectacles (SV). METHODS: This was a 
      randomized, controlled clinical trial involving subjects aged 8-12 with myopia of 
      -0.75 to -4.00D and astigmatism <1.00D allocated to MiSight((R)) study CLs group or 
      control group wearing SV. LD was determined at baseline, 12 and 24 months visit 
      with a validated device, Light Disturbance Analyzer (LDA) to determine the shape, 
      size and regularity of the LD phenomena with parameters of Light Disturbance 
      Index (LDI) Best Fit Circle (BFC) and Standard Deviation between LD and BFC 
      (BFC(Irreg.SD)). RESULTS: 74 children completed the study, 41 in the CL group and 
      33 in the SV group. SV group didn t show any significant differences between 
      monocular and binocular LD measurements throughout the study. Binocular 
      BFC(Radius) was smaller at 24 months visit compared with 12 month visit 
      (p < 0.05) and for BFC(Irreg.SD) was significantly smaller at 24 month visit 
      compared with baseline (p < 0.05). In MiSight((R)) group, binocular and monocular 
      LDI, BFC(Radius) and BFC(Irreg.SD) measurements didn't show any significant 
      change between 12 and 24 month visits (p > 0.05). However, monocular BFC(Irreg.) 
      as well as monocular and binocular BFC(Irreg.SD) showed a significant decrease at 
      24 month visit compared with 12 month visit. CONCLUSIONS: DF lenses increase the 
      monocular light disturbance perception compared with a single vision spectacle 
      correction. However, this effect decreased over the follow-up time and presented 
      a significant binocular attenuation effect.
CI  - Copyright (c) 2018 British Contact Lens Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Ruiz-Pomeda, A
AU  - Ruiz-Pomeda A
AD  - Department of Pharmacy, Biotechnology, Optics and Optometry, European University 
      of Madrid, Spain. Electronic address: alicia.ruiz@universidadeuropea.es.
FAU - Fernandes, P
AU  - Fernandes P
AD  - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of 
      Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal.
FAU - Amorim-de-Sousa, A
AU  - Amorim-de-Sousa A
AD  - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of 
      Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal.
FAU - Gonzalez-Meijome, J M
AU  - Gonzalez-Meijome JM
AD  - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of 
      Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal.
FAU - Prieto-Garrido, F L
AU  - Prieto-Garrido FL
AD  - Department Optics I: Optometry and Vision. Universidad Complutense de Madrid, 
      Madrid, Spain.
FAU - Perez-Sanchez, B
AU  - Perez-Sanchez B
AD  - Department of Statistics, Mathematics and Informatics. Area of Languages and 
      Computer Systems. Miguel Hernandez University of Elche, Spain.
FAU - Villa-Collar, C
AU  - Villa-Collar C
AD  - Doctoral and Research School, European University of Madrid, Spain.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181115
PL  - England
TA  - Cont Lens Anterior Eye
JT  - Contact lens & anterior eye : the journal of the British Contact Lens Association
JID - 9712714
SB  - IM
MH  - Child
MH  - *Contact Lenses, Hydrophilic
MH  - *Eyeglasses
MH  - Female
MH  - Humans
MH  - Male
MH  - Myopia/*therapy
MH  - Orthokeratologic Procedures
MH  - Vision Disorders/*physiopathology
MH  - Vision, Binocular/physiology
OTO - NOTNLM
OT  - Children
OT  - Dual focus contact lenses
OT  - Light disturbance
EDAT- 2018/11/19 06:00
MHDA- 2020/05/10 06:00
CRDT- 2018/11/19 06:00
PHST- 2018/03/13 00:00 [received]
PHST- 2018/11/05 00:00 [revised]
PHST- 2018/11/07 00:00 [accepted]
PHST- 2018/11/19 06:00 [pubmed]
PHST- 2020/05/10 06:00 [medline]
PHST- 2018/11/19 06:00 [entrez]
AID - S1367-0484(18)30381-3 [pii]
AID - 10.1016/j.clae.2018.11.006 [doi]
PST - ppublish
SO  - Cont Lens Anterior Eye. 2019 Apr;42(2):200-205. doi: 10.1016/j.clae.2018.11.006. 
      Epub 2018 Nov 15.