PMID- 30448468 OWN - NLM STAT- MEDLINE DCOM- 20190404 LR - 20190404 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 27 DP - 2019 Jan TI - Acute epileptic seizures in myelin oligodendrocyte glycoprotein encephalomyelitis and neuromyelitis optica spectrum disorder: A comparative cohort study. PG - 281-288 LID - S2211-0348(18)30492-9 [pii] LID - 10.1016/j.msard.2018.11.007 [doi] AB - BACKGROUND: Little is known about the incidence and characteristics of acute epileptic seizures in myelin oligodendrocyte glycoprotein encephalomyelitis (MOG-EM) and neuromyelitis optica spectrum disorder (NMOSD). In this study, we compared the incidence and characteristics of acute epileptic seizures in MOG-EM and NMOSD patients. METHODS: MOG-EM (n = 61) and NMOSD (n = 565) cases obtained from the MSNMOBase (2011-2018) were retrospectively reviewed. RESULTS: Acute epileptic seizures were observed in 13 (21.3%) patients with MOG-EM and two (0.4%) patients with NMOSD (P < 0.001). In both MOG-EM and NMOSD patients, more than half of seizures were single and of focal onset; slow wave and cortical/subcortical lesions were the most common abnormalities. In MOG-EM patients, no difference was found in the proportion of single seizure with and without anti-epileptic drugs (AEDs; 64.3% vs. 45.5%, P = 0.435). Long-term AED use did not significantly reduce the occurrence of acute epileptic seizures, which was 66.7% before and after treatment. In patients with MOG-EM and NMOSD, mycophenolate mofetil significantly reduced acute epileptic seizure occurrence (P = 0.024). CONCLUSION: Acute epileptic seizures were more common in MOG-EM patients than in NMOSD patients. The long-term use of AEDs might be unnecessary given the use of immunotherapy in cases of MOG-EM. CI - Copyright (c) 2018. Published by Elsevier B.V. FAU - Yao, Yuan AU - Yao Y AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Xu, Yan AU - Xu Y AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. Electronic address: xuyanpumch@hotmail.com. FAU - Ren, Haitao AU - Ren H AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Zhou, Xiangqin AU - Zhou X AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Jin, Liri AU - Jin L AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Huang, Yan AU - Huang Y AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Lu, Qiang AU - Lu Q AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Yang, Xunzhe AU - Yang X AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Zhang, Yao AU - Zhang Y AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Zhu, Yicheng AU - Zhu Y AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Peng, Bin AU - Peng B AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China. FAU - Cui, Liying AU - Cui L AD - Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Street, Dongcheng district, Beijing 100730, China; Neurosciences Center, Chinese Academy of Medical Sciences, No.3 Dongdan, Dongcheng district, Beijing 100730, China. LA - eng PT - Comparative Study PT - Journal Article DEP - 20181110 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 RN - 0 (Myelin-Oligodendrocyte Glycoprotein) SB - IM MH - Brain/pathology/physiopathology MH - Cohort Studies MH - Encephalomyelitis/*complications/pathology/physiopathology MH - Epilepsy/*complications MH - Female MH - Humans MH - Male MH - Myelin-Oligodendrocyte Glycoprotein/immunology MH - Neuromyelitis Optica/*complications/pathology/physiopathology MH - Seizures/*complications OTO - NOTNLM OT - Aquaporin 4 OT - Encephalomyelitis OT - Epileptic seizure OT - Myelin oligodendrocyte glycoprotein OT - Neuromyelitis optica spectrum disorder OT - Treatment EDAT- 2018/11/19 06:00 MHDA- 2019/04/05 06:00 CRDT- 2018/11/19 06:00 PHST- 2018/10/28 00:00 [received] PHST- 2018/11/04 00:00 [revised] PHST- 2018/11/09 00:00 [accepted] PHST- 2018/11/19 06:00 [pubmed] PHST- 2019/04/05 06:00 [medline] PHST- 2018/11/19 06:00 [entrez] AID - S2211-0348(18)30492-9 [pii] AID - 10.1016/j.msard.2018.11.007 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2019 Jan;27:281-288. doi: 10.1016/j.msard.2018.11.007. Epub 2018 Nov 10.