PMID- 30448485
OWN - NLM
STAT- MEDLINE
DCOM- 20200108
LR  - 20200108
IS  - 1532-9488 (Electronic)
IS  - 1043-0679 (Linking)
VI  - 31
IP  - 3
DP  - 2019 Autumn
TI  - Heparin-Induced Thrombocytopenia and Cardiac Surgery.
PG  - 335-344
LID - S1043-0679(18)30317-4 [pii]
LID - 10.1053/j.semtcvs.2018.10.011 [doi]
AB  - Heparin-induced thrombocytopenia (HIT) is an immune-mediated condition 
      characterized by thrombocytopenia with possible arterial and/or venous 
      thrombosis. The overall incidence of HIT is low but ranges from 0.1% to 5%.(1,2) 
      The incidence can be as high as 3% in patients undergoing cardiac surgery. The 
      use of unfractionated heparin (UFH) is ubiquitous in patients who undergo cardiac 
      procedures and carries a 10-fold higher incidence of HIT over low molecular 
      weight heparin. Patients undergoing cardiac surgery thus form a unique group that 
      warrants specific attention to this clinicopathologic entity considering the 
      relatively high incidence and associated morbidity and mortality with a delay in 
      diagnosis. In this article, we will discuss 5 clinical aspects pertinent to the 
      diagnosis and management of HIT in cardiac surgery patients and review the 
      current literature.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Solanki, Jigna
AU  - Solanki J
AD  - Department of Medicine, University of Virginia, Charlottesville, Virginia.
FAU - Shenoy, Sundeep
AU  - Shenoy S
AD  - Division of Cardiovascular Medicine, University of Arizona, Tuscan, Arizona.
FAU - Downs, Emily
AU  - Downs E
AD  - Department of Surgery, University of Virginia, Charlottesville, Virginia.
FAU - Palkimas, Surabhi
AU  - Palkimas S
AD  - Department of Pharmacy, University of Virginia, Charlottesville, Virginia.
FAU - Goldman, Svetlana
AU  - Goldman S
AD  - Department of Pharmacy, University of Virginia, Charlottesville, Virginia.
FAU - Sharma, Aditya M
AU  - Sharma AM
AD  - Division of Cardiovascular Medicine, University of Virginia, Charlottesville, 
      Virginia. Electronic address: sharmaam09@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181115
PL  - United States
TA  - Semin Thorac Cardiovasc Surg
JT  - Seminars in thoracic and cardiovascular surgery
JID - 8917640
RN  - 0 (Antibodies)
RN  - 0 (Anticoagulants)
RN  - 0 (Biomarkers)
RN  - 0 (PF4 protein, human)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Antibodies/blood
MH  - Anticoagulants/*adverse effects/immunology
MH  - Biomarkers/blood
MH  - Cardiac Surgical Procedures/*adverse effects/mortality
MH  - Heparin/*adverse effects/immunology
MH  - Humans
MH  - Incidence
MH  - Platelet Factor 4/immunology
MH  - Prognosis
MH  - Risk Factors
MH  - Thrombocytopenia/*chemically induced/immunology/mortality/therapy
OTO - NOTNLM
OT  - Cardiac surgery
OT  - HIT
OT  - Heparin induced thrombocytopenia
EDAT- 2018/11/19 06:00
MHDA- 2020/01/09 06:00
CRDT- 2018/11/19 06:00
PHST- 2018/10/08 00:00 [received]
PHST- 2018/10/16 00:00 [accepted]
PHST- 2018/11/19 06:00 [pubmed]
PHST- 2020/01/09 06:00 [medline]
PHST- 2018/11/19 06:00 [entrez]
AID - S1043-0679(18)30317-4 [pii]
AID - 10.1053/j.semtcvs.2018.10.011 [doi]
PST - ppublish
SO  - Semin Thorac Cardiovasc Surg. 2019 Autumn;31(3):335-344. doi: 
      10.1053/j.semtcvs.2018.10.011. Epub 2018 Nov 15.