PMID- 30449064
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20190221
IS  - 1438-8677 (Electronic)
IS  - 1435-8603 (Linking)
VI  - 21
IP  - 2
DP  - 2019 Mar
TI  - Accumulation patterns of endogenous beta-aminobutyric acid during plant development 
      and defence in Arabidopsis thaliana.
PG  - 318-325
LID - 10.1111/plb.12940 [doi]
AB  - We recently discovered that beta-aminobutyric acid (BABA), a molecule known for its 
      ability to prime defences in plants, is a natural plant metabolite. However, the 
      role played by endogenous BABA in plants is currently unknown. In this study we 
      investigated the systemic accumulation of BABA during pathogen infection, levels 
      of BABA during plant growth and development and analysed mutants possibly 
      involved in BABA transport or regulation. BABA was quantified by LC-MS using an 
      improved method adapted from a previously published protocol. Systemic 
      accumulation of BABA was determined by analysing non-infected leaves and roots 
      after localised infections with Plectosphaerella cucumerina or Pseudomonas 
      syringae pv. tomato (Pst) DC3000 avrRpt2. The levels of BABA were also quantified 
      in different plant tissues and organs during normal plant growth, and in leaves 
      during senescence. Mutants affecting amino acid transport (aap6, aap3, prot1 and 
      gat1), gamma-aminobutyric acid levels (pop2) and senescence/defence (cpr5-2) were 
      analysed. BABA was found to accumulate only locally after bacterial or fungal 
      infection, with no detectable increase in non-infected systemic plant parts. In 
      leaves, BABA content increased during natural and induced senescence. 
      Reproductive organs had the highest levels of BABA, and the mutant cpr5-2 
      produced constitutively high levels of BABA. Synthetic BABA is highly mobile in 
      the receiving plant, whereas endogenous BABA appears to be produced and 
      accumulated locally in a tissue-specific way. We discuss a possible role for BABA 
      in age-related resistance and propose a comprehensive model for endogenous and 
      synthetic BABA.
CI  - (c) 2018 German Society for Plant Sciences and The Royal Botanical Society of the 
      Netherlands.
FAU - Balmer, A
AU  - Balmer A
AD  - Institute of Biology, Laboratory of Molecular and Cell Biology, University of 
      Neuchatel, Neuchatel, Switzerland.
FAU - Glauser, G
AU  - Glauser G
AD  - Neuchatel Platform of Analytical Chemistry, University of Neuchatel, Neuchatel, 
      Switzerland.
FAU - Mauch-Mani, B
AU  - Mauch-Mani B
AD  - Institute of Biology, Laboratory of Molecular and Cell Biology, University of 
      Neuchatel, Neuchatel, Switzerland.
FAU - Baccelli, I
AU  - Baccelli I
AUID- ORCID: 0000-0002-1368-1250
AD  - Institute of Biology, Laboratory of Molecular and Cell Biology, University of 
      Neuchatel, Neuchatel, Switzerland.
AD  - Institute for Sustainable Plant Protection, National Research Council of Italy, 
      Sesto Fiorentino, Florence, Italy.
LA  - eng
GR  - 31003A-160162/Swiss National Science Foundation/
PT  - Journal Article
DEP - 20181210
PL  - England
TA  - Plant Biol (Stuttg)
JT  - Plant biology (Stuttgart, Germany)
JID - 101148926
RN  - 0 (Aminobutyrates)
RN  - 4282SA5CTS (3-aminobutyric acid)
SB  - IM
MH  - Aminobutyrates/*metabolism
MH  - Arabidopsis/*growth & development/metabolism
MH  - Phyllachorales
MH  - Plant Diseases/immunology/microbiology
MH  - *Plant Immunity
MH  - Plant Leaves/metabolism
MH  - Plant Roots/metabolism
MH  - Pseudomonas syringae
OTO - NOTNLM
OT  - BABA
OT  - cpr5
OT  - age-related resistance
OT  - defence
OT  - pathogen infection
OT  - priming
OT  - senescence
EDAT- 2018/11/19 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/11/19 06:00
PHST- 2018/09/04 00:00 [received]
PHST- 2018/11/09 00:00 [accepted]
PHST- 2018/11/19 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/11/19 06:00 [entrez]
AID - 10.1111/plb.12940 [doi]
PST - ppublish
SO  - Plant Biol (Stuttg). 2019 Mar;21(2):318-325. doi: 10.1111/plb.12940. Epub 2018 
      Dec 10.