PMID- 30450398
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 21
DP  - 2018 Dec
TI  - Pharmacokinetic data of synthetic cathinones in female Sprague-Dawley rats.
PG  - 1045-1050
LID - 10.1016/j.dib.2018.10.073 [doi]
AB  - The synthetic cathinones methylone, butylone, and pentylone differ from each 
      other through the one carbon lengthening of the alpha-alkyl chain: methylone (-CH3), 
      butylone (-CH2CH3), and pentylone (-CH2CH2CH3) while 
      3,4-methylenedioxymethamphetamine (MDMA) differs from methylone by a single 
      oxygen atom. Studies with MDMA, suggests that there may be male and female 
      pharmacokinetic and pharmacodynamic differences. In the present study, we present 
      the plasma pharmacokinetic data relative to a 20 mg/kg, subcutaneous doses of 
      methylone, butylone and pentylone in female Sprague-Dawley rats. Briefly, plasma 
      samples were collected via a jugular vein cannula, purified, and analyzed using a 
      HPLC system. While we have previously reported on the consistent relationship 
      between structure and pharmacokinetics of these synthetic cathinones in male, 
      Sprague-Dawley rats (Grecco and Sprague, 2016), this data set suggests that there 
      is no consistent relationship of chemical structure and pharmacokinetics of 
      methylone, butylone and pentylone in female Sprague-Dawley rats. The findings 
      from the present study further emphasize the need for the inclusion of female 
      subjects in the pharmacokinetic studies of synthetic cathinones as it is very 
      possible male-female differences may exist in rodent models.
FAU - Grecco, Gregory G
AU  - Grecco GG
AD  - The Ohio Attorney General׳s Center for the Future of Forensic Science, Bowling 
      Green State University, Bowling Green, OH 43403, USA.
AD  - Indiana University School of Medicine, Indianapolis, IN 46202, USA.
FAU - Kisor, David F
AU  - Kisor DF
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, Natural and Health 
      Sciences, Manchester University, Fort Wayne, IN 46845, USA.
FAU - Sprague, Jon E
AU  - Sprague JE
AD  - The Ohio Attorney General׳s Center for the Future of Forensic Science, Bowling 
      Green State University, Bowling Green, OH 43403, USA.
LA  - eng
PT  - Journal Article
DEP - 20181025
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC6226823
OTO - NOTNLM
OT  - AUC0-infinity, area under the concentration versus time curve
OT  - CLp, plasma clearance
OT  - Cmax, maximum concentration
OT  - EDTA, Ethylenediaminetetraacetic acid
OT  - JVC, Jugular Vein Cannula
OT  - MDMA, 3,4-methylenedioxymethamphetamine
OT  - SMBS, Sodium metabisulfite
OT  - Tmax, time of occurrence of maximum concentration
OT  - Vd, volume of distribution
OT  - sc, subcutaneous
EDAT- 2018/11/20 06:00
MHDA- 2018/11/20 06:01
PMCR- 2018/10/25
CRDT- 2018/11/20 06:00
PHST- 2018/08/17 00:00 [received]
PHST- 2018/10/11 00:00 [revised]
PHST- 2018/10/22 00:00 [accepted]
PHST- 2018/11/20 06:00 [entrez]
PHST- 2018/11/20 06:00 [pubmed]
PHST- 2018/11/20 06:01 [medline]
PHST- 2018/10/25 00:00 [pmc-release]
AID - S2352-3409(18)31290-3 [pii]
AID - 10.1016/j.dib.2018.10.073 [doi]
PST - epublish
SO  - Data Brief. 2018 Oct 25;21:1045-1050. doi: 10.1016/j.dib.2018.10.073. eCollection 
      2018 Dec.