PMID- 30450925
OWN - NLM
STAT- MEDLINE
DCOM- 20190905
LR  - 20240229
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 12
IP  - 11
DP  - 2018 Nov
TI  - The beta-blocker uptitration in elderly with heart failure regarding biomarker 
      levels: CIBIS-ELD substudy.
PG  - 1261-1270
LID - 10.2217/bmm-2018-0136 [doi]
AB  - AIM: We investigated if the baseline value of mid-regional pro-atrial natriuretic 
      peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing 
      beta-blocker uptitration in elderly patients with heart failure. PATIENTS & METHODS: 
      According to the biomarkers' levels, 457 patients were divided into three 
      subgroups and compared with each other at baseline and 3 months after. RESULTS: 
      All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had 
      significant amelioration of left ventricle ejection fraction and New York Heart 
      Association (NYHA) class after 3 months of beta-blocker uptitration (p < 0.001). 
      More prominent improvement of left ventricle ejection fraction and New York Heart 
      Association class was observed in subgroups with lower versus higher NPs levels. 
      CONCLUSION: NPs levels, unlike copeptin levels, might be useful tool for 
      objective selection of elderly heart failure patients who could have the greatest 
      benefit of forced uptitration.
FAU - Cvetinovic, Natasa
AU  - Cvetinovic N
AD  - Department of Cardiology, University Clinical Center Zvezdara, Belgrade, Serbia.
FAU - Sekularac, Nikola
AU  - Sekularac N
AD  - Department of Cardiology, University Clinical Center Zvezdara, Belgrade, Serbia.
FAU - Von Haehling, Stephan
AU  - Von Haehling S
AD  - Innovative Clinical Trials, Department of Cardiology & Pneumology, University of 
      Medicine Gottingen, Germany.
FAU - Tahirovic, Elvis
AU  - Tahirovic E
AD  - Department of Cardiology, Charite -Campus Virchow-Klinikum, Berlin, Germany.
FAU - Inkrot, Simona
AU  - Inkrot S
AD  - Department of Cardiology, Charite -Campus Virchow-Klinikum, Berlin, Germany.
FAU - Lainscak, Mitja
AU  - Lainscak M
AD  - Departments of Cardiology & Research & Education, General Hospital Celje, Celje, 
      Slovenia.
AD  - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
FAU - Apostolovic, Svetlana
AU  - Apostolovic S
AD  - Clinical Center Nis, Clinic for Cardiology, Nis, Serbia.
FAU - Putnikovic, Biljana
AU  - Putnikovic B
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
AD  - Department of Cardiology, University Hospital Zemun, Belgrade, Serbia.
FAU - Waagstein, Finn
AU  - Waagstein F
AD  - Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University 
      Hospital, Gothenburg, Sweden.
FAU - Gelbrich, Goetz
AU  - Gelbrich G
AD  - Coordination Centre for Clinical Trials Leipzig (KKSL), University of Leipzig, 
      Leipzig, Germany.
FAU - Aleksic, Andja
AU  - Aleksic A
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Loncar, Goran
AU  - Loncar G
AD  - School of Medicine, University of Belgrade, Belgrade, Serbia.
AD  - Cardiology Department, Cardiovascular Institute Dedinje, Belgrade, Serbia.
FAU - Dungen, Hans-Dirk
AU  - Dungen HD
AD  - Department of Cardiology, Charite -Campus Virchow-Klinikum, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20181119
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Biomarkers)
RN  - 0 (Glycopeptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (copeptins)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adrenergic beta-Antagonists/*administration & dosage
MH  - Aged
MH  - Biomarkers/blood
MH  - Double-Blind Method
MH  - Female
MH  - Glycopeptides/*blood
MH  - *Heart Failure/blood/drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - *Stroke Volume
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - N-terminal pro B-type natriuretic peptide
OT  - chronic heart failure
OT  - copeptin
OT  - mid-regional pro-atrial natriuretic peptide
OT  - beta-blocker uptitration
EDAT- 2018/11/20 06:00
MHDA- 2019/09/07 06:00
CRDT- 2018/11/20 06:00
PHST- 2018/11/20 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
PHST- 2018/11/20 06:00 [entrez]
AID - 10.2217/bmm-2018-0136 [doi]
PST - ppublish
SO  - Biomark Med. 2018 Nov;12(11):1261-1270. doi: 10.2217/bmm-2018-0136. Epub 2018 Nov 
      19.