PMID- 30452875
OWN - NLM
STAT- MEDLINE
DCOM- 20191227
LR  - 20231006
IS  - 1551-5044 (Electronic)
IS  - 0022-1554 (Print)
IS  - 0022-1554 (Linking)
VI  - 67
IP  - 3
DP  - 2019 Mar
TI  - Leukocyte Nucleus Reveals a Linear Order of Chromosomes Separated in Two Parental 
      Genomes That Favors the Process of Gene Activation.
PG  - 151-158
LID - 10.1369/0022155418812879 [doi]
AB  - Analysis of trisomy 8 cells and the chromosome-specific fluorescence in situ 
      hybridization (FISH) signals on the ring-shaped nucleus of a neutrophil reveal 
      that homologue chromosomes orient in diametrical opposition to each other. This 
      positioning results in a separation of the two haploid sets of parental 
      chromosomes organized as two exclusive groups. These two groups impart the 
      nucleus a symmetry that fortifies immune protection by accelerating chemotaxis. 
      The ring form of the nucleus is a legacy of the orientation of chromosomes as a 
      rosette during metaphase and telophase stages. A dual control maintains this 
      spatial order: (1) chromosomes are tethered to the centriole all through the cell 
      cycle, and (2) during their circular orientation in telophase the chromosomes 
      bind to each other with lamins, which reorganize the nuclear membrane of the 
      daughter nuclei, generating an additional anchorage. Here, chromosomes serve as 
      temporary packets to assure proper distribution of the nuclear DNA during 
      mitosis. The remainder time of the cell cycle the chromosomes are chained 
      together across the telomeres, allowing a continuous sequence of genes of the two 
      genomes, maternal and paternal, thus facilitating easy reading of the gene 
      sequence. Exceptions to these orders are either physiological and temporary, or 
      pathological and disease causing.
FAU - Chaudhuri, Jyoti P
AU  - Chaudhuri JP
AD  - LMU Kinderpoliklinik, Tumorcytogenetic Unit, Munich, Germany.
AD  - Jena University Hospital, Institute of Human Genetics, Friedrich Schiller 
      University, Jena, Germany.
FAU - Karamanov, Sultan
AU  - Karamanov S
AD  - Quest Diagnostics (Med Fusion), Lewisville, TX.
FAU - Scott, Liliana
AU  - Scott L
AD  - Inform Diagnostics, Phoenix, AZ.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Jena University Hospital, Institute of Human Genetics, Friedrich Schiller 
      University, Jena, Germany.
FAU - Walther, Joachim U
AU  - Walther JU
AD  - Zentrum Humangenetik und Laboratoriumsdiagnostik, Martinsried, Germany.
LA  - eng
PT  - Journal Article
DEP - 20181119
PL  - United States
TA  - J Histochem Cytochem
JT  - The journal of histochemistry and cytochemistry : official journal of the 
      Histochemistry Society
JID - 9815334
RN  - 0 (Lamins)
RN  - Chromosome 8, trisomy
SB  - IM
MH  - Cell Nucleus/*metabolism/ultrastructure
MH  - Centrioles/metabolism/ultrastructure
MH  - Chemotaxis/genetics/immunology
MH  - Chromosomes, Human, Pair 8/genetics/immunology
MH  - Cytogenetic Analysis
MH  - Female
MH  - *Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Inheritance Patterns
MH  - *Karyotype
MH  - Lamins/genetics/metabolism
MH  - Male
MH  - Metaphase
MH  - Neutrophils/immunology/*metabolism/ultrastructure
MH  - Telophase
MH  - Trisomy/*genetics/immunology/pathology
PMC - PMC6393843
OTO - NOTNLM
OT  - chromosome organization
OT  - contest and concordance of the parental genes
OT  - cytogenetics and gene activation
OT  - leukocytes
OT  - nuclear morphology and function
COIS- Competing Interests: The author(s) declared no potential conflicts of interest 
      with respect to the research, authorship, and/or publication of this article.
EDAT- 2018/11/20 06:00
MHDA- 2019/12/28 06:00
PMCR- 2020/03/01
CRDT- 2018/11/20 06:00
PHST- 2018/11/20 06:00 [pubmed]
PHST- 2019/12/28 06:00 [medline]
PHST- 2018/11/20 06:00 [entrez]
PHST- 2020/03/01 00:00 [pmc-release]
AID - 10.1369_0022155418812879 [pii]
AID - 10.1369/0022155418812879 [doi]
PST - ppublish
SO  - J Histochem Cytochem. 2019 Mar;67(3):151-158. doi: 10.1369/0022155418812879. Epub 
      2018 Nov 19.