PMID- 30453671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220129
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 7
IP  - 11
DP  - 2018 Nov 18
TI  - Predictors of Exercise Capacity in Patients with Hypertrophic Obstructive 
      Cardiomyopathy.
LID - 10.3390/jcm7110447 [doi]
LID - 447
AB  - Hypertrophic obstructive cardiomyopathy (HOCM) patients exhibit compromised peak 
      exercise capacity (VO(2)peak). Importantly, severely reduced VO(2)peak is directly 
      related to increased morbidity and mortality in these patients. Therefore, we 
      sought to determine clinical predictors of VO(2)peak in HOCM patients. HOCM 
      patients who performed symptom-limited cardiopulmonary exercise testing between 
      1995 and 2016 were included for analysis. Peak VO(2) was reported as absolute peak 
      VO(2), indexed to body weight and analyzed as quartiles, with quartile 1 
      representing the lowest VO(2)peak. Step-wise regression models using demographic 
      features and clinical and physiologic characteristics were created to determine 
      predictors of HOCM patients with the lowest VO(2)peak. We included 1177 HOCM 
      patients (age: 53 +/- 14 years; BMI: 24 +/- 12 kg/m(2)) with a VO(2)peak of 18.0 +/- 5.6 
      mL/kg/min. Significant univariate predictors of the lowest VO(2)peak included age, 
      female sex, New York Health Association (NYHA) class, BMI, left atrial volume 
      index, E/e', E/A, hemoglobin, N-terminal pro b-type natriuretic peptide 
      (NT-proBNP), and a history of diabetes, hypertension, stroke, atrial 
      fibrillation, or coronary artery disease. Independent predictors of the lowest 
      VO(2)peak included age (OR, CI: 1.03, 1.02(-)1.06; p < 0.0001), women (4.66, 
      2.94(-)7.47; p = 0.001), a history of diabetes (2.05, 1.17(-)3.60; p = 0.01), BMI 
      (0.94, 0.92(-)0.96; p < 0.0001), left atrial volume index (1.07, 1.05(-)1.21; p = 
      0.04), E/e' (1.05, 1.01(-)1.08; p = 0.004), hemoglobin (0.76, 0.65(-)0.88; p = 
      0.0004), and NT-proBNP (1.72, 1.42(-)2.11; p < 0.0001). These findings demonstrate 
      that demographic factors (i.e., age and sex), comorbidities (e.g., diabetes and 
      obesity), echocardiography indices, and biomarkers (e.g., hemoglobin and 
      NT-proBNP) are predictive of severely compromised VO(2)peak in HOCM patients.
FAU - Smith, Joshua R
AU  - Smith JR
AUID- ORCID: 0000-0002-3687-6261
AD  - Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo 
      Clinic, Rochester, MN 55095, USA. smith.joshua1@mayo.edu.
FAU - Medina-Inojosa, Jose R
AU  - Medina-Inojosa JR
AUID- ORCID: 0000-0001-8705-0462
AD  - Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo 
      Clinic, Rochester, MN 55095, USA. medinaInojosa.jose@mayo.edu.
FAU - Layrisse, Veronica
AU  - Layrisse V
AD  - Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo 
      Clinic, Rochester, MN 55095, USA. veronicall@sanjuanbautista.edu.
AD  - San Juan Bautista School of Medicine, Caguas, PR 00727, USA. 
      veronicall@sanjuanbautista.edu.
FAU - Ommen, Steve R
AU  - Ommen SR
AD  - Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo 
      Clinic, Rochester, MN 55095, USA. ommen.steve@mayo.edu.
FAU - Olson, Thomas P
AU  - Olson TP
AD  - Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo 
      Clinic, Rochester, MN 55095, USA. olson.thomas2@mayo.edu.
LA  - eng
GR  - 18POST3990251/American Heart Association/
GR  - 18POST33990251/AHA/American Heart Association-American Stroke Association/United 
      States
GR  - HL-126638/Foundation for the National Institutes of Health/
GR  - R25 HL092621/HL/NHLBI NIH HHS/United States
GR  - R25-HL092621/Foundation for the National Institutes of Health/
PT  - Journal Article
DEP - 20181118
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6262545
OTO - NOTNLM
OT  - exercise capacity
OT  - exercise testing
OT  - hypertrophic cardiomyopathy
COIS- The authors declare no conflicts of interest.
EDAT- 2018/11/21 06:00
MHDA- 2018/11/21 06:01
PMCR- 2018/11/18
CRDT- 2018/11/21 06:00
PHST- 2018/10/15 00:00 [received]
PHST- 2018/11/08 00:00 [revised]
PHST- 2018/11/14 00:00 [accepted]
PHST- 2018/11/21 06:00 [entrez]
PHST- 2018/11/21 06:00 [pubmed]
PHST- 2018/11/21 06:01 [medline]
PHST- 2018/11/18 00:00 [pmc-release]
AID - jcm7110447 [pii]
AID - jcm-07-00447 [pii]
AID - 10.3390/jcm7110447 [doi]
PST - epublish
SO  - J Clin Med. 2018 Nov 18;7(11):447. doi: 10.3390/jcm7110447.