PMID- 30454861
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 47
IP  - 3
DP  - 2019 May-Jun
TI  - Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by 
      CD4(+) T cells in allergic rhinitis.
PG  - 234-240
LID - S0301-0546(18)30109-5 [pii]
LID - 10.1016/j.aller.2018.07.003 [doi]
AB  - INTRODUCTION AND OBJECTIVES: Allergic rhinitis (AR) is a classic Th2-mediated 
      disease, with important contributions to the pathology of interleukins 4, 5, and 
      13. The co-stimulatory molecule of OX40 and its ligand interaction participate in 
      the immune response by regulation of Th1/Th2 cells balance. Considering the 
      paucity of information on the relation between OX40 ligand (OX40L) and AR, this 
      study aimed to examine its expression on B lymphocytes. PATIENTS AND METHODS: 
      This case-control study consisted of 20 AR patients and 20 healthy subjects. The 
      serum level of total immunoglobulin E (IgE) was measured using the 
      electro-chemiluminescence (ECL) technology. The percentage of B-lymphocytes 
      expressing OX40L was assessed by flow cytometry. The amounts of IL-4 in CD4(+) T 
      cells culture supernatant was also measured by the enzyme-linked immunosorbent 
      assay (ELISA). RESULTS: OX40L expression on B lymphocytes of patients was 
      significantly higher than the control group (44.32+/-19.21% vs. 2.79+/-2.48% 
      respectively, p<0.001). In AR patients, OX40L expression correlated positively 
      with the levels of serum total IgE and IL-4 produced by CD4(+) T lymphocytes 
      (p<0.01 - p<0.05) respectively. CONCLUSIONS: Collectively, the findings of this 
      work suggest that there is a relationship between the OX40L expression level on B 
      lymphocytes and allergic markers such as IgE and IL-4 in patients with allergic 
      rhinitis.
CI  - Copyright (c) 2018 SEICAP. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Fouladi, S
AU  - Fouladi S
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Masjedi, M
AU  - Masjedi M
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - G Hakemi, M
AU  - G Hakemi M
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Ghasemi, R
AU  - Ghasemi R
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Eskandari, N
AU  - Eskandari N
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran; Applied Physiology Research Center, Isfahan University 
      of Medical Sciences, Isfahan, Iran. Electronic address: neskandari@med.mui.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20181116
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Biomarkers)
RN  - 0 (CD4 Antigens)
RN  - 0 (OX40 Ligand)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - Adolescent
MH  - Adult
MH  - B-Lymphocytes/*immunology
MH  - Biomarkers/*blood
MH  - CD4 Antigens/metabolism
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Interleukin-4/*blood
MH  - Male
MH  - Middle Aged
MH  - OX40 Ligand/*metabolism
MH  - Rhinitis, Allergic/*immunology
MH  - Th2 Cells/*immunology
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Immunoglobulin E
OT  - Interleukin-4
OT  - OX40 ligand
EDAT- 2018/11/21 06:00
MHDA- 2019/08/09 06:00
CRDT- 2018/11/21 06:00
PHST- 2018/05/09 00:00 [received]
PHST- 2018/07/07 00:00 [revised]
PHST- 2018/07/19 00:00 [accepted]
PHST- 2018/11/21 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2018/11/21 06:00 [entrez]
AID - S0301-0546(18)30109-5 [pii]
AID - 10.1016/j.aller.2018.07.003 [doi]
PST - ppublish
SO  - Allergol Immunopathol (Madr). 2019 May-Jun;47(3):234-240. doi: 
      10.1016/j.aller.2018.07.003. Epub 2018 Nov 16.