PMID- 30455158
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20220129
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 61
DP  - 2019 Apr
TI  - The minimum clinically important difference (MCID) for a falls intervention in 
      Parkinson's: A delphi study.
PG  - 106-110
LID - S1353-8020(18)30489-9 [pii]
LID - 10.1016/j.parkreldis.2018.11.008 [doi]
AB  - BACKGROUND: Falls are common in Parkinson's disease so any intervention that 
      reduced falls risk would be of value. One potential intervention is the use of 
      cholinesterase inhibitor (ChEi) drugs. OBJECTIVE: To establish the minimum 
      clinically important difference (MCID) for fall rates to inform the effect 
      estimate for sample size calculations of future clinical trials. METHODS: We 
      performed a Delphi study assembling a panel of experts in Parkinson's disease 
      from academic and clinical medicine in order to reach a consensus of opinion. 
      Responses from a panel were summarised and resent to the group, until consensus 
      was reached. RESULTS: 780 clinicians, who had been caring for people with 
      Parkinson's for an average of 14 years, were contacted via three routes. The 
      median (Interquartile range (IQR)) MCID after round 1 was 25% (IQR 20-30%) which 
      equates to the prevention of 5 (IQR 4-6) falls per year. Increasing consensus 
      after round two confirmed the MCID of 25%, narrowing the (IQ) range to 20%-25%. 
      This was unchanged when the panel were shown the number of participants that 
      would need to be recruited to a clinical trial in order to achieve this 
      difference. CONCLUSIONS: We have established that an expert panel of PD 
      specialists consider that an intervention that demonstrated a 25% (IQR 20-25%) 
      relative reduction in falls rate would be clinically meaningful. This estimate 
      can be used to help determine the sample size for any future clinical trial.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Henderson, Emily J
AU  - Henderson EJ
AD  - Department of Population Health Sciences, Bristol Medical School, University of 
      Bristol, 39 Whatley Road, Bristol, BS8 2PS, United Kingdom; Royal United 
      Hospitals NHS Foundation Trust Bath, BA1 3NG, United Kingdom. Electronic address: 
      Emily.henderson@bristol.ac.uk.
FAU - Morgan, Gemma S
AU  - Morgan GS
AD  - Department of Population Health Sciences, Bristol Medical School, University of 
      Bristol, 39 Whatley Road, Bristol, BS8 2PS, United Kingdom.
FAU - Amin, Jigisha
AU  - Amin J
AD  - Faculty of Health Sciences, Bristol Medical School, University of Bristol, 
      Bristol, BS8 2PS, United Kingdom.
FAU - Gaunt, Daisy M
AU  - Gaunt DM
AD  - Bristol Randomised Trials Collaboration (BRTC), Department of Population Health 
      Sciences, Bristol Medical School, University of Bristol, 39 Whatley Road, 
      Bristol, BS8 2PS, United Kingdom.
FAU - Ben-Shlomo, Yoav
AU  - Ben-Shlomo Y
AD  - Department of Population Health Sciences, Bristol Medical School, University of 
      Bristol, 39 Whatley Road, Bristol, BS8 2PS, United Kingdom.
LA  - eng
GR  - F-1003/PUK_/Parkinson's UK/United Kingdom
GR  - J-0901/PUK_/Parkinson's UK/United Kingdom
PT  - Journal Article
DEP - 20181108
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - 0 (Cholinesterase Inhibitors)
SB  - IM
MH  - Accidental Falls/*prevention & control
MH  - Cholinesterase Inhibitors/therapeutic use
MH  - Delphi Technique
MH  - Geriatricians
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - Neurologists
MH  - Parkinson Disease/*rehabilitation
OTO - NOTNLM
OT  - Cholinesterase inhibitors
OT  - Delphi technique
OT  - Falls
OT  - Parkinson disease
OT  - Sample size
EDAT- 2018/11/21 06:00
MHDA- 2020/05/06 06:00
CRDT- 2018/11/21 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/10/19 00:00 [revised]
PHST- 2018/11/05 00:00 [accepted]
PHST- 2018/11/21 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2018/11/21 06:00 [entrez]
AID - S1353-8020(18)30489-9 [pii]
AID - 10.1016/j.parkreldis.2018.11.008 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2019 Apr;61:106-110. doi: 
      10.1016/j.parkreldis.2018.11.008. Epub 2018 Nov 8.