PMID- 30459022
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 157
DP  - 2018
TI  - Brain temperature: from physiology and pharmacology to neuropathology.
PG  - 483-504
LID - B978-0-444-64074-1.00030-6 [pii]
LID - 10.1016/B978-0-444-64074-1.00030-6 [doi]
AB  - Brain temperature is a physiologic parameter that depends on metabolism-related 
      intracerebral heat production and heat loss by cerebral circulation to the rest 
      of the body and then to the external environment. Despite the importance of 
      temperature as a metabolism-related parameter and a factor affecting neural 
      activity and function, it is generally believed that brain temperature is a 
      tightly regulated and highly stable homeostatic parameter. To challenge this 
      view, we present data on fluctuations in brain temperature occurring in rats 
      following exposure to various arousing stimuli and during different behaviors and 
      discuss their mechanisms. Since most psychoactive drugs affect brain metabolism 
      and vascular tone, thereby altering heat production and heat loss, we consider 
      changes in brain temperature induced by several types of psychoactive drugs. Our 
      focus here is on several widely used drugs of abuse (i.e., cocaine, heroin, 
      methylenedioxymethamphetamine (MDMA)), which are used by humans at widely varying 
      doses and often under conditions of psychophysiologic activation and in 
      environments limiting natural heat loss. In contrast to physiologic brain 
      hyperthermia that has a clear adaptive significance, drug-induced hyperthermia 
      can reach pathologic levels, resulting in irreversible damage of brain cells, 
      profound leakage of the blood-brain barrier, and multiple functional 
      perturbations that can, in certain instances, be incompatible with life. We also 
      discuss the complexities of considering brain temperature within the frameworks 
      of physiologic regulation and homeostasis. While different adaptive mechanisms 
      could, within some limits, compensate for an altered heat balance of the brain, 
      real-life challenges often create situations where this balance cannot be 
      adequately compensated for, resulting in acute life-threatening health 
      complications and chronic neuropathology.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kiyatkin, Eugene A
AU  - Kiyatkin EA
AD  - Behavioral Neuroscience Branch, National Institute on Drug Abuse - Intramural 
      Research Program, National Institutes of Health, Baltimore, MD, United States. 
      Electronic address: ekiyatki@intra.nida.nih.gov.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Body Temperature/*drug effects/*physiology
MH  - *Brain/drug effects/metabolism/pathology
MH  - Cerebrovascular Circulation/drug effects/physiology
MH  - Homeostasis/*drug effects/physiology
MH  - Humans
MH  - *Neuropathology
MH  - Psychotropic Drugs/*pharmacology
OTO - NOTNLM
OT  - arousing stimuli
OT  - brain hyperthermia
OT  - brain hypothermia
OT  - cocaine
OT  - heroin
OT  - metabolic brain activation
OT  - neuropathology
OT  - psychomotor stimulants
OT  - vasoconstriction/vasodilation
EDAT- 2018/11/22 06:00
MHDA- 2019/03/05 06:00
CRDT- 2018/11/22 06:00
PHST- 2018/11/22 06:00 [entrez]
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
AID - B978-0-444-64074-1.00030-6 [pii]
AID - 10.1016/B978-0-444-64074-1.00030-6 [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2018;157:483-504. doi: 10.1016/B978-0-444-64074-1.00030-6.