PMID- 30459579
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240214
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 12
DP  - 2018
TI  - Resting State Connectivity Between Medial Temporal Lobe Regions and Intrinsic 
      Cortical Networks Predicts Performance in a Path Integration Task.
PG  - 415
LID - 10.3389/fnhum.2018.00415 [doi]
LID - 415
AB  - Humans differ in their individual navigational performance, in part because 
      successful navigation relies on several diverse abilities. One such navigational 
      capability is path integration, the updating of position and orientation during 
      movement, typically in a sparse, landmark-free environment. This study examined 
      the relationship between path integration abilities and functional connectivity 
      to several canonical intrinsic brain networks. Intrinsic networks within the 
      brain reflect past inputs and communication as well as structural architecture. 
      Individual differences in intrinsic connectivity have been observed for common 
      networks, suggesting that these networks can inform our understanding of 
      individual spatial abilities. Here, we examined individual differences in 
      intrinsic connectivity using resting state magnetic resonance imaging (rsMRI). We 
      tested path integration ability using a loop closure task, in which participants 
      viewed a single video of movement in a circle trajectory in a sparse environment, 
      and then indicated whether the video ended in the same location in which it 
      started. To examine intrinsic brain networks, participants underwent a resting 
      state scan. We found that better performance in the loop task was associated with 
      increased connectivity during rest between the central executive network (CEN) 
      and posterior hippocampus, parahippocampal cortex (PHC) and entorhinal cortex. We 
      also found that connectivity between PHC and the default mode network (DMN) 
      during rest was associated with better loop closure performance. The results 
      indicate that interactions between medial temporal lobe (MTL) regions and 
      intrinsic networks that involve prefrontal cortex (PFC) are important for path 
      integration and navigation.
FAU - Izen, Sarah C
AU  - Izen SC
AD  - Department of Psychological & Brain Sciences and Center for Memory & Brain, 
      Boston University, Boston, MA, United States.
FAU - Chrastil, Elizabeth R
AU  - Chrastil ER
AD  - Department of Psychological & Brain Sciences and Center for Memory & Brain, 
      Boston University, Boston, MA, United States.
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Boston, MA, United States.
AD  - Department of Geography, University of California, Santa Barbara, Santa Barbara, 
      CA, United States.
FAU - Stern, Chantal E
AU  - Stern CE
AD  - Department of Psychological & Brain Sciences and Center for Memory & Brain, 
      Boston University, Boston, MA, United States.
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Boston, MA, United States.
LA  - eng
GR  - P41 RR014075/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20181016
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC6232837
OTO - NOTNLM
OT  - central executive network
OT  - default mode network
OT  - executive function
OT  - fronto-parietal
OT  - memory
OT  - navigation
OT  - path integration
OT  - resting state
EDAT- 2018/11/22 06:00
MHDA- 2018/11/22 06:01
PMCR- 2018/01/01
CRDT- 2018/11/22 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/09/25 00:00 [accepted]
PHST- 2018/11/22 06:00 [entrez]
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2018/11/22 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2018.00415 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2018 Oct 16;12:415. doi: 10.3389/fnhum.2018.00415. 
      eCollection 2018.