PMID- 30459713
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210503
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Intraoperative Decision-Making and Technical Aspects of Parathyroidectomy in 
      Young Patients With MEN1 Related Hyperparathyroidism.
PG  - 618
LID - 10.3389/fendo.2018.00618 [doi]
LID - 618
AB  - One in 5,000 to 1 in 50,000 births have multiple endocrine neoplasia type 1 
      (MEN1). MEN1 is a hereditary syndrome clinically defined by the presence of two 
      of the following endocrine tumors in the same patient: parathyroid adenomas, 
      entero-pancreatic endocrine tumors and pituitary tumors. Most commonly, patients 
      with MEN1 manifest primarily with signs and symptoms linked to primary 
      hyperparathyroidism. By age 50, it is estimated that 100% of patients with MEN1 
      will have been diagnosed with primary hyperparathyroidism. These patients will 
      need to undergo resection of their hyperfunctioning glands, however there is no 
      clear consensus on which procedure to perform and when to perform it in these 
      patients. In this original study we describe and explain the rational of our 
      peri-operative approach and management at MD Anderson Cancer Center of MEN1 
      patients with hyperparathyroidism. This protocol includes preoperative 
      evaluation, intraoperative decision-making and detailed surgical technique 
      adopted for these patients' care. Additionally we review follow-up and disease 
      management in instances of recurrent primary hyperparathyroidism in patients with 
      MEN1 syndrome.
FAU - Nobecourt, Priscilla F
AU  - Nobecourt PF
AD  - Department of Surgery, University of Texas Medical Branch, Galveston, TX, United 
      States.
FAU - Zagzag, Jonathan
AU  - Zagzag J
AD  - Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 
      Houston, TX, United States.
FAU - Asare, Elliot A
AU  - Asare EA
AD  - Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 
      Houston, TX, United States.
FAU - Perrier, Nancy D
AU  - Perrier ND
AD  - Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 
      Houston, TX, United States.
LA  - eng
PT  - Journal Article
DEP - 20181016
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6232704
OTO - NOTNLM
OT  - MEN1
OT  - decision making
OT  - hypercalcemia
OT  - hyperparathyroidism
OT  - parathyroidectomy
OT  - recurrence
OT  - subtotal parathyroidectomy
OT  - technique
EDAT- 2018/11/22 06:00
MHDA- 2018/11/22 06:01
PMCR- 2018/01/01
CRDT- 2018/11/22 06:00
PHST- 2018/04/13 00:00 [received]
PHST- 2018/09/27 00:00 [accepted]
PHST- 2018/11/22 06:00 [entrez]
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2018/11/22 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00618 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Oct 16;9:618. doi: 10.3389/fendo.2018.00618. 
      eCollection 2018.