PMID- 30459887
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1793-5482 (Print)
IS  - 2248-9614 (Electronic)
VI  - 13
IP  - 4
DP  - 2018 Oct-Dec
TI  - Adverse Event with the Use of Carmustine Wafers and Postoperative 
      Radiochemotherapy for the Treatment of High-grade Glioma.
PG  - 1171-1174
LID - 10.4103/ajns.AJNS_235_16 [doi]
AB  - Randomized, controlled trials have shown significant improvement of survival 
      after implantation of 1,3-bis(2-Chloroethyl)-1-nitrosourea (BCNU) wafers for 
      patients suffering from high-grade glioma. A combination of local chemotherapy 
      with BCNU and concomitant radiochemotherapy with temozolomide (TMZ) appears to be 
      attractive to enhance the overall survival, even though these treatments may 
      potentially cumulate their toxicity. We report a clinical case of a patient 
      submitted to this combined treatment protocol. Severe brain edema and a cystic 
      formation in the surgical cavity rapidly developed. Data supporting the use of 
      Gliadel(R) combined with TMZ comes from small retrospective studies, and some 
      series have shown a very high rate of adverse events (AEs) when this 
      multimodality treatment is applied. Combined protocols of local and systemic 
      chemotherapy might provide survival benefits, although AEs seem currently 
      underestimated.
FAU - Salle, Federico
AU  - Salle F
AD  - Department of Neurosurgery, Assistance Publique-Hopitaux de Paris, Groupe 
      Hospitalier Henri-Mondor Albert-Chenevier, PePsy Department, F-94010 Creteil, 
      France.
AD  - U955 INSERM IMRB eq. 14 Universite Paris 12 UPEC, Faculte de Medecine, F-94010 
      Creteil, France.
AD  - Department of Neurosurgery, Hospital Maciel-ASSE, Montevideo, Uruguay.
FAU - Lahiani, Wissem
AU  - Lahiani W
AD  - Department of Neurosurgery, Assistance Publique-Hopitaux de Paris, Groupe 
      Hospitalier Henri-Mondor Albert-Chenevier, PePsy Department, F-94010 Creteil, 
      France.
FAU - Spagnuolo, Edgardo
AU  - Spagnuolo E
AD  - Department of Neurosurgery, Hospital Maciel-ASSE, Montevideo, Uruguay.
FAU - Palfi, Stephane
AU  - Palfi S
AD  - Department of Neurosurgery, Assistance Publique-Hopitaux de Paris, Groupe 
      Hospitalier Henri-Mondor Albert-Chenevier, PePsy Department, F-94010 Creteil, 
      France.
AD  - U955 INSERM IMRB eq. 14 Universite Paris 12 UPEC, Faculte de Medecine, F-94010 
      Creteil, France.
LA  - eng
PT  - Case Reports
PL  - India
TA  - Asian J Neurosurg
JT  - Asian journal of neurosurgery
JID - 101564712
PMC - PMC6208266
OTO - NOTNLM
OT  - Adverse events
OT  - Gliadel
OT  - carmustine wafers
OT  - high-grade glioma
COIS- There are no conflicts of interest.
EDAT- 2018/11/22 06:00
MHDA- 2018/11/22 06:01
PMCR- 2018/10/01
CRDT- 2018/11/22 06:00
PHST- 2018/11/22 06:00 [entrez]
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2018/11/22 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - AJNS-13-1171 [pii]
AID - 10.4103/ajns.AJNS_235_16 [doi]
PST - ppublish
SO  - Asian J Neurosurg. 2018 Oct-Dec;13(4):1171-1174. doi: 10.4103/ajns.AJNS_235_16.