PMID- 30461316
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1558-9455 (Electronic)
IS  - 1558-9447 (Print)
IS  - 1558-9447 (Linking)
VI  - 15
IP  - 3
DP  - 2020 May
TI  - Interpreting Patient-Reported Outcome Results: Is One Minimum Clinically 
      Important Difference Really Enough?
PG  - 360-364
LID - 10.1177/1558944718812180 [doi]
AB  - Background: Patient-reported outcomes (PROs) are the gold standard for reporting 
      clinical outcomes in research. A crucial component of interpreting PROs is the 
      minimum clinically important difference (MCID). Patient-Rated Wrist Evaluation 
      (PRWE) is a disease-specific PRO tool developed for use in distal radius 
      fractures. The purpose of this study was to determine the influence of injury 
      characteristics, treatment modality, and calculation methodology on the PRWE MCID 
      in distal radius fractures. We hypothesize the MCID would be significantly 
      influenced by each of these factors. Methods: From 2014 to 2016, 197 patients 
      with a distal radius fracture were treated at a single level I trauma center. 
      Each patient was asked to complete a PRWE survey at preoperative baseline, 6-week 
      postoperative, and 12-week postoperative dates. The MCID was derived utilizing 2 
      distinct strategies, anchor and distribution. Anchor questions involved overall 
      health anchor and mental and emotional health anchor. Patient variables regarding 
      demographics, injury characteristics, and treatment modality were collected. 
      Results: The MCID was unique between analytical methods at all time points. The 
      distribution MCID presented commonality across assessed variables. However, the 
      anchor MCID was unique by AO/OTA fracture classifications, treatment modality, 
      and time points. Conclusions: Our study found the MCID was heavily influenced by 
      assessment time points, analytical method, treatment modality, and fracture 
      classification. These results suggest that to accurately interpret PRO data in 
      clinical trials, an anchor question should be included so that the MCID can be 
      determined for the specific patient population included in the study.
FAU - McCreary, Dylan L
AU  - McCreary DL
AD  - University of Minnesota, Minneapolis, USA.
FAU - Sandberg, Benjamin C
AU  - Sandberg BC
AD  - University of Minnesota, Minneapolis, USA.
AD  - Regions Hospital, Saint Paul, MN, USA.
FAU - Bohn, Debra C
AU  - Bohn DC
AD  - University of Minnesota, Minneapolis, USA.
AD  - TRIA Orthopaedic Center, Bloomington, MN, USA.
FAU - Parikh, Harsh R
AU  - Parikh HR
AD  - University of Minnesota, Minneapolis, USA.
AD  - Regions Hospital, Saint Paul, MN, USA.
FAU - Cunningham, Brian P
AU  - Cunningham BP
AD  - University of Minnesota, Minneapolis, USA.
AD  - Regions Hospital, Saint Paul, MN, USA.
AD  - TRIA Orthopaedic Center, Bloomington, MN, USA.
LA  - eng
PT  - Journal Article
DEP - 20181121
PL  - United States
TA  - Hand (N Y)
JT  - Hand (New York, N.Y.)
JID - 101264149
SB  - IM
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - Pain Measurement
MH  - *Patient Reported Outcome Measures
MH  - Treatment Outcome
MH  - Wrist Joint
PMC - PMC7225877
OTO - NOTNLM
OT  - distal radius fracture
OT  - minimum clinically important difference (MCID)
OT  - outcomes
OT  - patient-rated wrist evaluation (PRWE)
OT  - patient-reported outcomes
COIS- Declaration of Conflicting Interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: DCB reports financial interests with Bristol-Myers 
      Squibb, Eli Lilly, and Pfizer outside the submitted work. DCB also serves on the 
      Board of the American Academy of Orthopaedic Surgeons, Ruth Jackson Orthopaedic 
      Society, and TRIA Orthopaedic Center for Research & Education. BPC reports that 
      his spouse is the CEO and Founder of CODE Technology. DLM, BCS, and HRP have no 
      conflicts to report.
EDAT- 2018/11/22 06:00
MHDA- 2021/07/29 06:00
PMCR- 2021/05/01
CRDT- 2018/11/22 06:00
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2018/11/22 06:00 [entrez]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 10.1177_1558944718812180 [pii]
AID - 10.1177/1558944718812180 [doi]
PST - ppublish
SO  - Hand (N Y). 2020 May;15(3):360-364. doi: 10.1177/1558944718812180. Epub 2018 Nov 
      21.