PMID- 30461438
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190906
IS  - 1538-2982 (Electronic)
IS  - 1056-6163 (Linking)
VI  - 28
IP  - 1
DP  - 2019 Feb
TI  - The Influence of Type 2 Diabetes Mellitus on the Osseointegration of Titanium 
      Implants With Different Surface Modifications-A Histomorphometric Study in 
      High-Fat Diet/Low-Dose Streptozotocin-Treated Rats.
PG  - 11-19
LID - 10.1097/ID.0000000000000836 [doi]
AB  - OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a systemic disease that also 
      compromises the bone healing capacity. In healthy individuals, surface 
      modifications of dental implants are proven to increase bone response and implant 
      success. The aim of this study was to clarify if the surface modifications also 
      improve osseointegration in a setting with diabetes mellitus. METHODS: T2DM was 
      induced in 7 rats by a high-fat diet/low-dose streptozotocin injection. All 
      animals received a hydroxyapatite (HA) implant, a sandblasted and acid-etched 
      (SLA) implant, and a standard machined titanium implant for control in the tibia. 
      After 4 weeks, thin-ground sections were produced, and the volume of new bone 
      formation (nBV/TV) and bone-to-implant contact (nB.I/Im.I) were 
      histomorphometrically analyzed. RESULTS: Both surface modifications led to an 
      increase of osseointegration compared with the machined surface implant in rats 
      with T2DM. nBV/TV was highest in the SLA implants, whereas nB.I/Im.I was highest 
      in the HA group. Regardless of the surface modification, a superordinate regional 
      pattern of new bone formation over the length of the implant was observed. 
      CONCLUSIONS: Implants with HA coating and SLA surface modifications seem to have 
      the potential to increase osseointegration also in T2DM rats when compared with a 
      conventional machined surface.
FAU - Zhou, Wenjuan
AU  - Zhou W
AD  - Dentist, Department of Implant Dentistry, Yantai Stomatological Hospital, 
      Shangdong, China.
AD  - Research Fellow, Karl Donath Laboratory for Hard Tissue and Biomaterial Research, 
      Division of Conservative Dentistry and Periodontology, Competence Center for 
      Periodontal Research, University Clinic of Dentistry, Medical University of 
      Vienna, Vienna, Austria.
FAU - Tangl, Stefan
AU  - Tangl S
AD  - Head of Laboratory, Karl Donath Laboratory for Hard Tissue and Biomaterial 
      Research, Division of Oral Surgery, School of Dentistry, Austrian Cluster for 
      Tissue Regeneration, Medical University of Vienna, Vienna, Austria.
FAU - Reich, Karoline Maria
AU  - Reich KM
AD  - Research Fellow, Karl Donath Laboratory for Hard Tissue and Biomaterial Research, 
      Division of Oral Surgery, School of Dentistry, Austrian Cluster for Tissue 
      Regeneration, Medical University of Vienna, Vienna, Austria.
FAU - Kirchweger, Franziska
AU  - Kirchweger F
AD  - Research Associate, Karl Donath Laboratory for Hard Tissue and Biomaterial 
      Research, Division of Oral Surgery, School of Dentistry, Medical University of 
      Vienna, Austria and Austrian Cluster for Tissue Regeneration, Vienna, Austria.
FAU - Liu, Zhonghao
AU  - Liu Z
AD  - Professor and Chairman, Department of Implant Dentistry, Yantai Stomatological 
      Hospital, Professor, Shandong University, Shangdong, China.
FAU - Zechner, Werner
AU  - Zechner W
AD  - Professor and Deputy Head, Division of Oral Surgery, School of Dentistry, Medical 
      University of Vienna, Vienna, Austria.
FAU - Ulm, Christian
AU  - Ulm C
AD  - Professor and Head, Division of Oral Surgery, School of Dentistry, Medical 
      University of Vienna, Vienna, Austria.
FAU - Rausch-Fan, Xiaohui
AU  - Rausch-Fan X
AD  - Professor and Head, Competence Center for Periodontal Research, Head for 
      Periodontology and Prophylaxis, Division of Conservative Dentistry and 
      Periodontology, School of Dentistry, Medical University of Vienna, Vienna, 
      Austria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Implant Dent
JT  - Implant dentistry
JID - 9206481
RN  - 0 (Dental Implants)
RN  - 5W494URQ81 (Streptozocin)
RN  - 91D9GV0Z28 (Durapatite)
RN  - D1JT611TNE (Titanium)
MH  - Acid Etching, Dental
MH  - Animals
MH  - Dental Implantation, Endosseous/*methods
MH  - *Dental Implants
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diet, High-Fat
MH  - Durapatite
MH  - Implants, Experimental
MH  - Male
MH  - Osseointegration/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/administration & dosage
MH  - Surface Properties
MH  - Tibia/surgery
MH  - Titanium
EDAT- 2018/11/22 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/11/22 06:00
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/11/22 06:00 [entrez]
AID - 10.1097/ID.0000000000000836 [doi]
PST - ppublish
SO  - Implant Dent. 2019 Feb;28(1):11-19. doi: 10.1097/ID.0000000000000836.