PMID- 30462494
OWN - NLM
STAT- MEDLINE
DCOM- 20200123
LR  - 20201209
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 20
IP  - 1
DP  - 2019 Jan 14
TI  - Lubrication and Wear Protection of Micro-Structured Hydrogels Using Bioinspired 
      Fluids.
PG  - 326-335
LID - 10.1021/acs.biomac.8b01311 [doi]
AB  - We report the fabrication and the use of a bioinspired synovial fluid acting as a 
      lubricant fluid and antiwear agent at soft and porous chitosan hydrogel 
      tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) 
      and a bottle-brush polymer (BB) having a polycationic attachment group and 
      polyzwitterionic pendant chains. The 2.5%(w/w) chitosan hydrogel plugs are 
      organized in a bilayered structure exposing a thin and dense superficial zone 
      (SZ), covering a porous deep zone (DZ), and exhibiting microchannels 
      perpendicularly aligned to the SZ. Using a low-load tribometer, the addition of 
      HA lubricating solution at the hydrogel-hydrogel rubbing contact drastically 
      decreased the coefficient of friction (CoF) from mu = 0.20 +/- 0.01 to 0.04 +/- 0.01 
      on the DZ configuration and from mu = 0.31 +/- 0.01 to 0.08 +/- 0.01 on the SZ surface 
      when increasing the HA concentration from 0 to 1000 mug/mL and its molecular mass 
      from 10 to 1500 kDa, similar to what was found when using the BB polymer alone. 
      When combining the BB polymer and the 1500 kDa HA, the CoF remained stable at mu = 
      0.04 +/- 0.01 for both studied contact configurations, highlighting the synergistic 
      interaction of the two macromolecules. Hydrogel wear was characterized by 
      assessing the final gel surface roughness by the means of an interferometer. 
      Increasing HA concentration and molecular weight plus the addition of the BB 
      polymer led to a dramatic surface wear protection with a final gel surface 
      roughness of the hydrogels similar to the untested gels. In brief, the BB polymer 
      in combination with high molecular weight HA is a potential lubricating fluid as 
      well as a wear resistant agent for soft materials lubrication and wear 
      protection.
FAU - Faivre, Jimmy
AU  - Faivre J
AD  - Ingenierie des Materiaux Polymeres, IMP- CNRS UMR 5223 , Universite de Lyon, 
      Universite Claude Bernard Lyon 1 , 15 Boulevard Latarjet , 69622 Villeurbanne 
      Cedex , France.
AD  - Canadian Research Chair in Bioinspired Materials, Faculty of Pharmacy , 
      Universite de Montreal , Montreal , Qc H3T 1J4 , Canada.
FAU - Montembault, Alexandra
AU  - Montembault A
AD  - Ingenierie des Materiaux Polymeres, IMP- CNRS UMR 5223 , Universite de Lyon, 
      Universite Claude Bernard Lyon 1 , 15 Boulevard Latarjet , 69622 Villeurbanne 
      Cedex , France.
FAU - Sudre, Guillaume
AU  - Sudre G
AD  - Ingenierie des Materiaux Polymeres, IMP- CNRS UMR 5223 , Universite de Lyon, 
      Universite Claude Bernard Lyon 1 , 15 Boulevard Latarjet , 69622 Villeurbanne 
      Cedex , France.
FAU - Shrestha, Buddha Ratna
AU  - Shrestha BR
AD  - Canadian Research Chair in Bioinspired Materials, Faculty of Pharmacy , 
      Universite de Montreal , Montreal , Qc H3T 1J4 , Canada.
FAU - Xie, Guojun
AU  - Xie G
AD  - Center for Macromolecular Engineering, Department of Chemistry , Carnegie Mellon 
      University , Pittsburgh , Pennsylvania 15213 , United States.
FAU - Matyjaszewski, Krzysztof
AU  - Matyjaszewski K
AUID- ORCID: 0000-0003-1960-3402
AD  - Center for Macromolecular Engineering, Department of Chemistry , Carnegie Mellon 
      University , Pittsburgh , Pennsylvania 15213 , United States.
FAU - Benayoun, Stephane
AU  - Benayoun S
AD  - Laboratoire de Tribologie et Dynamique des Systemes, CNRS UMR 5513 , Ecole 
      Centrale de Lyon , 36 Avenue Guy de Collongue , 69134 Ecully Cedex , France.
FAU - Banquy, Xavier
AU  - Banquy X
AUID- ORCID: 0000-0002-3342-3179
AD  - Canadian Research Chair in Bioinspired Materials, Faculty of Pharmacy , 
      Universite de Montreal , Montreal , Qc H3T 1J4 , Canada.
FAU - Delair, Thierry
AU  - Delair T
AD  - Ingenierie des Materiaux Polymeres, IMP- CNRS UMR 5223 , Universite de Lyon, 
      Universite Claude Bernard Lyon 1 , 15 Boulevard Latarjet , 69622 Villeurbanne 
      Cedex , France.
FAU - David, Laurent
AU  - David L
AUID- ORCID: 0000-0003-3632-8537
AD  - Ingenierie des Materiaux Polymeres, IMP- CNRS UMR 5223 , Universite de Lyon, 
      Universite Claude Bernard Lyon 1 , 15 Boulevard Latarjet , 69622 Villeurbanne 
      Cedex , France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20181204
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Hydrogels)
RN  - 0 (Lubricants)
RN  - 0 (Polyamines)
RN  - 0 (Polyelectrolytes)
RN  - 0 (polycations)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Biomimetic Materials/*chemistry
MH  - Chitosan/analogs & derivatives
MH  - Friction
MH  - Hyaluronic Acid/chemistry
MH  - Hydrogels/*chemistry
MH  - Lubricants/*chemistry
MH  - Polyamines/chemistry
MH  - Polyelectrolytes
MH  - Synovial Fluid/chemistry
EDAT- 2018/11/22 06:00
MHDA- 2020/01/24 06:00
CRDT- 2018/11/22 06:00
PHST- 2018/11/22 06:00 [pubmed]
PHST- 2020/01/24 06:00 [medline]
PHST- 2018/11/22 06:00 [entrez]
AID - 10.1021/acs.biomac.8b01311 [doi]
PST - ppublish
SO  - Biomacromolecules. 2019 Jan 14;20(1):326-335. doi: 10.1021/acs.biomac.8b01311. 
      Epub 2018 Dec 4.