PMID- 30463426
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Jan
TI  - The Minimal Clinically Important Difference and Substantial Clinical Benefit in 
      the Patient-Reported Outcome Measures of Patients Undergoing Osteochondral 
      Allograft Transplantation in the Knee.
PG  - 42-50
LID - 10.1177/1947603518812552 [doi]
AB  - OBJECTIVE: Little is known regarding the minimal clinically important difference 
      (MCID) and substantial clinical benefit (SCB) with regard to the Knee injury and 
      Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee 
      (IKDC) Subjective Knee Evaluation Form, Lysholm score, and Short Form 12 (SF-12) 
      score of patients who undergo osteochondral allograft transplantation (OCA). We 
      aimed to determine the MCID and SCB associated with those patient-reported 
      outcome measures (PROMs) after OCA. DESIGN: We analyzed the data of 86 
      consecutive patients who underwent OCA and who completed satisfaction surveys at 
      a minimum of 1 year postoperatively and had at least one repeated PROM. MCID was 
      determined using an anchor-based method: the optimal cutoff point for receiver 
      operative characteristic (ROC) curves. If an anchor-based method was 
      inapplicable, distribution-based methods were employed. SCB was determined using 
      ROC curve analysis. RESULTS: Based on the ROC curve analysis, MCID was 16.7 for 
      KOOS pain, 25 for KOOS sports/recreation, and 9.8 for IKDC. SCB was 27.7 for KOOS 
      pain, 10.7 for KOOS symptom, 30 for KOOS sports/recreation, 31.3 for KOOS quality 
      of life, 26.9 for IKDC, 25 for Lysholm, and 12.1 for SF-12 physical component 
      summary. No significant association was noted between SCB achievement and the 
      baseline patient factors and baseline PROMs. CONCLUSION: We demonstrated the 
      MCIDs and SCBs of several PROMs in patients undergoing OCA. These results will 
      aid the interpretation of the effect of treatment and clinical trial settings. 
      Moreover, the SCBs will help surgeons in the counseling of patients, where 
      patients expect optimal results rather than minimal improvement.
FAU - Ogura, Takahiro
AU  - Ogura T
AD  - Sports Medicine Center, Funabashi Orthopedic Hospital, Funabashi, Chiba, Japan.
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
FAU - Ackermann, Jakob
AU  - Ackermann J
AUID- ORCID: 0000-0002-4063-5815
AD  - Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA, USA.
FAU - Mestriner, Alexandre Barbieri
AU  - Mestriner AB
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
FAU - Merkely, Gergo
AU  - Merkely G
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - Department of Traumatology, Semmelweis University, Budapest, Hungary.
FAU - Gomoll, Andreas H
AU  - Gomoll AH
AD  - Hospital for Special Surgery, New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20181122
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - Adult
MH  - Arthroplasty, Subchondral/methods/*psychology
MH  - Cartilage/transplantation
MH  - Female
MH  - Functional Status
MH  - Humans
MH  - Knee Injuries/psychology/*surgery
MH  - Knee Joint/*surgery
MH  - Male
MH  - *Minimal Clinically Important Difference
MH  - *Patient Reported Outcome Measures
MH  - Patient Satisfaction/statistics & numerical data
MH  - Quality of Life
MH  - ROC Curve
MH  - Transplantation, Homologous
MH  - Treatment Outcome
PMC - PMC7755969
OTO - NOTNLM
OT  - International Knee Documentation Committee
OT  - Knee injury and Osteoarthritis Outcome Score
OT  - Lysholm score
OT  - Short Form 12
OT  - minimal clinically important difference
OT  - osteochondral allograft transplantation
OT  - substantial clinical benefit
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/11/23 06:00
MHDA- 2021/10/29 06:00
PMCR- 2021/07/01
CRDT- 2018/11/23 06:00
PHST- 2018/11/23 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2018/11/23 06:00 [entrez]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 10.1177_1947603518812552 [pii]
AID - 10.1177/1947603518812552 [doi]
PST - ppublish
SO  - Cartilage. 2021 Jan;12(1):42-50. doi: 10.1177/1947603518812552. Epub 2018 Nov 22.