PMID- 30464294
OWN - NLM
STAT- MEDLINE
DCOM- 20191216
LR  - 20201224
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 19
IP  - 2
DP  - 2019 Feb
TI  - Dendritic cell subsets in T cell programming: location dictates function.
PG  - 89-103
LID - 10.1038/s41577-018-0088-1 [doi]
AB  - Dendritic cells (DCs) can be viewed as translators between innate and adaptive 
      immunity. They integrate signals derived from tissue infection or damage and 
      present processed antigen from these sites to naive T cells in secondary lymphoid 
      organs while also providing multiple soluble and surface-bound signals that help 
      to guide T cell differentiation. DC-mediated tailoring of the appropriate T cell 
      programme ensures a proper cascade of immune responses that adequately targets 
      the insult. Recent advances in our understanding of the different types of DC 
      subsets along with the cellular organization and orchestration of DC and 
      lymphocyte positioning in secondary lymphoid organs over time has led to a 
      clearer understanding of how the nature of the T cell response is shaped. This 
      Review discusses how geographical organization and ordered sequences of cellular 
      interactions in lymph nodes and the spleen regulate immunity.
FAU - Eisenbarth, S C
AU  - Eisenbarth SC
AD  - Department of Laboratory Medicine, Immunobiology, Section of Allergy & 
      Immunology, Yale University School of Medicine, New Haven, CT, USA. 
      stephanie.eisenbarth@yale.edu.
LA  - eng
GR  - R01 AI108829/AI/NIAID NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Lymph Nodes/immunology
MH  - Lymphocyte Activation/immunology
MH  - Spleen/immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC7755085
MID - NIHMS1653179
EDAT- 2018/11/23 06:00
MHDA- 2019/12/18 06:00
PMCR- 2020/12/22
CRDT- 2018/11/23 06:00
PHST- 2018/11/23 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/11/23 06:00 [entrez]
PHST- 2020/12/22 00:00 [pmc-release]
AID - 10.1038/s41577-018-0088-1 [pii]
AID - 10.1038/s41577-018-0088-1 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2019 Feb;19(2):89-103. doi: 10.1038/s41577-018-0088-1.