PMID- 30465441
OWN - NLM
STAT- MEDLINE
DCOM- 20190430
LR  - 20190430
IS  - 1876-2891 (Electronic)
IS  - 1876-2883 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Feb 8
TI  - Bifidobacterium longum IM55 and Lactobacillus plantarum IM76 alleviate allergic 
      rhinitis in mice by restoring Th2/Treg imbalance and gut microbiota disturbance.
PG  - 55-67
LID - 10.3920/BM2017.0146 [doi]
AB  - This study aimed to examine whether probiotics, which suppressed the 
      differentiation of splenic T cells into type 2 helper T (Th2) cells and induced 
      into regulatory T cells in vitro, alleviate allergic rhinitis (AR) and gut 
      microbiota disturbance. We isolated Bifidobacterium longum IM55 and Lactobacillus 
      plantarum IM76 from human faecal microbiota and kimchi, respectively, and 
      examined their effects on ovalbumin (OVA)-induced AR and gut microbiota 
      disturbance in mice. Treatment with IM55, IM76, or their probiotic mixture (PM) 
      significantly reduced OVA-induced allergic nasal symptoms and blood 
      immunoglobulin E (IgE) levels in mice. These also reduced OVA-induced interleukin 
      (IL)-4 and IL-5 levels in nasal tissues and bronchoalveolar lavage fluid (BALF) 
      but increased OVA-suppressed IL-10 levels. Treatment with IM55, IM76, or PM 
      reduced OVA-induced increase in the populations of mast cells, eosinophils, and 
      Th2 cells and increased OVA-suppressed population of regulatory T cells in the 
      BALF. Treatment with IM55, IM76, or PM also inhibited OVA-induced expression of 
      IL-5 in lung and colon tissues and restored OVA-disturbed composition of gut 
      microbiota Proteobacteria, Bacteroidetes, and Actinobacteria. These results 
      suggest that IM55 and IM67 can alleviate AR by restoring Th2/Treg imbalance and 
      gut microbiota disturbance.
FAU - Kim, W-G
AU  - Kim WG
AD  - 1 Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, 
      Dongdaemun-gu, Seoul 02447, Republic of Korea.
FAU - Kang, G-D
AU  - Kang GD
AD  - 2 Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung 
      Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of 
      Korea.
FAU - Kim, H I
AU  - Kim HI
AD  - 1 Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, 
      Dongdaemun-gu, Seoul 02447, Republic of Korea.
FAU - Han, M J
AU  - Han MJ
AD  - 1 Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, 
      Dongdaemun-gu, Seoul 02447, Republic of Korea.
FAU - Kim, D-H
AU  - Kim DH
AD  - 2 Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung 
      Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of 
      Korea.
AD  - 3 Neurobiota Research Center, Kyung Hee University, 26, Kyungheedae-ro, 
      Dongdaemun-gu, Seoul 02447, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20181122
PL  - Netherlands
TA  - Benef Microbes
JT  - Beneficial microbes
JID - 101507616
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Bifidobacterium longum/*physiology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Colon/immunology
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Dysbiosis/chemically induced/*therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Lactobacillus plantarum/*physiology
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/toxicity
MH  - Probiotics/pharmacology
MH  - Rhinitis, Allergic/chemically induced/*therapy
MH  - Spleen/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - IL-5
OT  - IgE
OT  - allergic rhinitis
EDAT- 2018/11/23 06:00
MHDA- 2019/05/01 06:00
CRDT- 2018/11/23 06:00
PHST- 2018/11/23 06:00 [pubmed]
PHST- 2019/05/01 06:00 [medline]
PHST- 2018/11/23 06:00 [entrez]
AID - 10.3920/BM2017.0146 [doi]
PST - ppublish
SO  - Benef Microbes. 2019 Feb 8;10(1):55-67. doi: 10.3920/BM2017.0146. Epub 2018 Nov 
      22.