PMID- 30468784
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20210816
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 141
DP  - 2019 Jan
TI  - Association between ESR1 polymorphisms and second to fourth digit ratio in 
      school-aged children in the Hokkaido Study.
PG  - 55-62
LID - S0039-128X(18)30215-0 [pii]
LID - 10.1016/j.steroids.2018.11.011 [doi]
AB  - The ratio of the lengths of the 2nd and 4th digits (2D:4D) is considered an index 
      of prenatal exposure to androgen. Indeed, androgen receptors have been linked to 
      digit length, but estrogen receptors are rarely investigated in this context. 
      Thus, we investigated the association between estrogen receptor 1 (ESR1) genetic 
      polymorphisms and 2D:4D in school-aged children. The 2D:4D ratios were determined 
      using Vernier calipers from photocopies of palms provided by 1800 children aged 
      7 years who were enrolled in an ongoing prospective cohort study in Hokkaido, 
      Japan. The children were genotyped using cord blood collected at birth for single 
      nucleotide polymorphisms in ESR1, specifically PvuII (T > C, dbSNP: rs2234693), 
      XbaI (A > G, dbSNP: rs9340799), and rs2077647 (A > G). The association between 
      ESR1 polymorphisms and 2D:4D was assessed by multiple linear regression adjusted 
      for potential cofounding factors. Boys with the GG genotype at rs9340799 had a 
      significantly lower 2D:4D in the right hand than boys with the AA/AG genotype 
      (-0.96% lower, 95% confidence interval: -1.68 to -0.24). However, this 
      association was detected only in boys born to non-smoking mothers. No significant 
      differences were found between rs9340799 polymorphisms and 2D:4D among girls. 
      There was also no link between 2D:4D and polymorphisms at rs2234693 and 
      rs2077647. These data suggest that rs9340799 polymorphisms in ESR1 may contribute 
      to digit length and 2D:4D.
CI  - Copyright (c) 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Nishimura, Yoko
AU  - Nishimura Y
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan; Center 
      for Environmental and Health Sciences, Hokkaido University, North-12, West-7, 
      Kita-ku, Sapporo 060-0812, Japan.
FAU - Moriya, Kimihiko
AU  - Moriya K
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan. 
      Electronic address: k-moriya@med.hokudai.ac.jp.
FAU - Kobayashi, Sumitaka
AU  - Kobayashi S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Araki, Atsuko
AU  - Araki A
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Sata, Fumihiro
AU  - Sata F
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Health Center, Chuo University, 42-8, 
      Ichigaya-Hommura-cho, Shinjuku-ku, Tokyo 162-8473, Japan.
FAU - Mitsui, Takahiko
AU  - Mitsui T
AD  - Department of Urology, Graduate School of Medical Science, University of 
      Yamanashi, Simokato-1110, Chuo 409-3898, Japan.
FAU - Itoh, Sachiko
AU  - Itoh S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Miyashita, Chihiro
AU  - Miyashita C
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Cho, Kazutoshi
AU  - Cho K
AD  - Maternity and Perinatal Care Center, Hokkaido University Hospital, North-14, 
      West-5 Kita-ku, Sapporo 060-8648, Japan.
FAU - Kon, Masafumi
AU  - Kon M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Nakamura, Michiko
AU  - Nakamura M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Kitta, Takeya
AU  - Kitta T
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Murai, Sachiyo
AU  - Murai S
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Kishi, Reiko
AU  - Kishi R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Shinohara, Nobuo
AU  - Shinohara N
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181122
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Child
MH  - Cohort Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prospective Studies
OTO - NOTNLM
OT  - Digit ratio
OT  - ESR1 polymorphism
OT  - Estrogen receptor alpha
EDAT- 2018/11/24 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/11/24 06:00
PHST- 2018/08/10 00:00 [received]
PHST- 2018/11/14 00:00 [revised]
PHST- 2018/11/17 00:00 [accepted]
PHST- 2018/11/24 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/11/24 06:00 [entrez]
AID - S0039-128X(18)30215-0 [pii]
AID - 10.1016/j.steroids.2018.11.011 [doi]
PST - ppublish
SO  - Steroids. 2019 Jan;141:55-62. doi: 10.1016/j.steroids.2018.11.011. Epub 2018 Nov 
      22.