PMID- 30469046
OWN - NLM
STAT- MEDLINE
DCOM- 20190530
LR  - 20190530
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 174
DP  - 2019 Feb 1
TI  - Multi-functional core-shell Fe(3)O(4)@Au nanoparticles for cancer diagnosis and 
      therapy.
PG  - 252-259
LID - S0927-7765(18)30780-X [pii]
LID - 10.1016/j.colsurfb.2018.11.004 [doi]
AB  - Multi-functional core-shell Fe(3)O(4)@Au nanoparticles 
      (Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs) conjugated with doxorubicin (DOX), methoxy 
      poly(ethylene glycol) (mPEG), and folic acid-linked poly(ethylene glycol) 
      (PEG-FA) were synthesized for cancer theranostic applications. In the developed 
      NPs, the DOX was chemically conjugated at the surface of core-shell Fe(3)O(4)@Au 
      NPs using L-cysteine methyl ester (LCME) as a linker by acid-sensitive hydrazone 
      bond. The formation of Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs was confirmed by (1)H-NMR 
      analysis. The TEM image and DLS studies showed that the mean diameter of the 
      prepared NPs was about 18 and 38 nm, respectively. Due to the existence of 
      superparamagnetic Fe(3)O(4), the Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs presented the 
      saturation magnetization (Ms) value of 23 emu/g. The developed NPs displayed the 
      maximum amount of drug release in the acidic medium than that in the mild 
      alkaline medium because of the presence of acid-sensitive hydrazone bond. Due to 
      the presence of FA, the Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs displayed the increased 
      cellular uptake through a folate-receptor-mediated endocytosis, which results in 
      the improved cytotoxic effect on the HeLa cells. Under the laser irradiation, the 
      cytotoxicity of Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs was found to be improved due to 
      the photothermal effect of Au shell existing in the NPs. These results reveal 
      that the Fe(3)O(4)@Au-DOX-mPEG/PEG-FA NPs could be a promising tumour-targeted 
      drug delivery system with the capabilities of combined MR/CT imaging, 
      photothermal, and chemotherapy of tumours.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - S, Rajkumar
AU  - S R
AD  - Department of Chemistry, Hindustan Institute of Technology and Science, Padur, 
      Chennai, 603 103, India.
FAU - M, Prabaharan
AU  - M P
AD  - Department of Chemistry, Hindustan Institute of Technology and Science, Padur, 
      Chennai, 603 103, India. Electronic address: mprabaharan@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20181115
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Drug Carriers)
RN  - 0 (Ferric Compounds)
RN  - 1K09F3G675 (ferric oxide)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-57-5 (Gold)
RN  - 80168379AG (Doxorubicin)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Antibiotics, Antineoplastic/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Doxorubicin/chemistry/*pharmacology
MH  - Drug Carriers/chemistry
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - Ferric Compounds/*chemistry
MH  - Folic Acid/chemistry
MH  - Gold/*chemistry
MH  - HeLa Cells
MH  - Humans
MH  - Metal Nanoparticles/*chemistry
MH  - Optical Imaging
MH  - Particle Size
MH  - Polyethylene Glycols/chemistry
MH  - Structure-Activity Relationship
MH  - Surface Properties
MH  - Uterine Cervical Neoplasms/*diagnostic imaging/*drug therapy
OTO - NOTNLM
OT  - Cancer therapy
OT  - Core-shell nanoparticles
OT  - Drug delivery
OT  - Multi-functional
OT  - Theranostics
EDAT- 2018/11/24 06:00
MHDA- 2019/05/31 06:00
CRDT- 2018/11/24 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/11/01 00:00 [revised]
PHST- 2018/11/03 00:00 [accepted]
PHST- 2018/11/24 06:00 [pubmed]
PHST- 2019/05/31 06:00 [medline]
PHST- 2018/11/24 06:00 [entrez]
AID - S0927-7765(18)30780-X [pii]
AID - 10.1016/j.colsurfb.2018.11.004 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2019 Feb 1;174:252-259. doi: 
      10.1016/j.colsurfb.2018.11.004. Epub 2018 Nov 15.