PMID- 30469093
OWN - NLM
STAT- MEDLINE
DCOM- 20200122
LR  - 20200122
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 81
DP  - 2019 Mar-Apr
TI  - Inter-muscular adipose tissue is associated with adipose tissue inflammation and 
      poorer functional performance in central adiposity.
PG  - 1-7
LID - S0167-4943(18)30213-9 [pii]
LID - 10.1016/j.archger.2018.11.006 [doi]
AB  - BACKGROUND: The presence of concomitant sarcopenia and obesity in sarcopenic 
      obesity (SO) confers worse functional, morbidity and mortality outcomes compared 
      to either alone. Excess adiposity and central redistribution of fats are 
      associated with systemic inflammation and ectopic tissue fat infiltration in 
      forms of Intermuscular adipose tissue (IMAT). Our study examines the profile of 
      IMAT across a spectrum of body compositions and associations with physical 
      performance and inflammatory biomarkers including Monocyte Chemoattractant 
      Protein-1 (MCP-1), a novel biomarker of adipose tissue inflammation. METHODS: 187 
      community dwelling elderly participants were recruited and classified into 4 
      subgroups: normal, obese, sarcopenia and SO, using validated criteria for 
      sarcopenia and waist circumference to define central obesity. We performed 
      magnetic resonance imaging of mid-thigh sections to segment IMAT and muscle. 
      Participants were assessed for muscle strength, physical performance and blood 
      inflammatory biomarkers of interleukin-6, C-Reactive Protein and MCP-1. We 
      examined correlation of IMAT(ratio) with muscle function measures and blood 
      biomarkers. Multiple regression analyses were used to examine the association of 
      body composition types and IMAT(ratio) with muscle function. RESULTS: IMAT(ratio) 
      was highest in SO and obese groups. Overall, higher IMAT(ratio) is significantly 
      associated with raised MCP-1, lower gait speed and muscle strength. SO had lowest 
      scores in Short Physical Performance Battery (SPPB), gait speed, hand-grip and 
      knee extension strength. IMAT(ratio) is independently associated with SPPB and 
      handgrip strength, whilst SO is independently associated with muscle strength. 
      CONCLUSION: Our results suggest the possible role of IMAT as a candidate imaging 
      biomarker for adipose tissue inflammation and associated poorer functional 
      outcomes in SO.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Lim, Jun Pei
AU  - Lim JP
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore; Institute of 
      Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore. Electronic 
      address: Jun_Pei_LIM@ttsh.com.sg.
FAU - Chong, Mei Sian
AU  - Chong MS
AD  - Geriatric Education and Research Institute, Singapore.
FAU - Tay, Laura
AU  - Tay L
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore; 
      Department of General Medicine, Sengkang General Hospital, Singapore.
FAU - Yang, Yu Xin
AU  - Yang YX
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore; 
      Ageing Research Institute for Society and Education (ARISE), Nanyang 
      Technological University, Singapore.
FAU - Leung, Bernard P
AU  - Leung BP
AD  - Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 
      Singapore.
FAU - Yeo, Audrey
AU  - Yeo A
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Yew, Suzanne
AU  - Yew S
AD  - Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
FAU - Tan, Cher Heng
AU  - Tan CH
AD  - Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
FAU - Lim, Wee Shiong
AU  - Lim WS
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore; Institute of 
      Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181113
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adipose Tissue/*diagnostic imaging
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/blood
MH  - Female
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Interleukin-6/blood
MH  - Knee Joint/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Obesity, Abdominal/*metabolism/physiopathology
MH  - Sarcopenia/*metabolism
MH  - Walking Speed/physiology
OTO - NOTNLM
OT  - Intermuscular adipose tissue
OT  - Monocyte Chemoattractant Protein-1
OT  - Sarcopenic obesity
EDAT- 2018/11/24 06:00
MHDA- 2020/01/23 06:00
CRDT- 2018/11/24 06:00
PHST- 2018/08/16 00:00 [received]
PHST- 2018/11/02 00:00 [revised]
PHST- 2018/11/10 00:00 [accepted]
PHST- 2018/11/24 06:00 [pubmed]
PHST- 2020/01/23 06:00 [medline]
PHST- 2018/11/24 06:00 [entrez]
AID - S0167-4943(18)30213-9 [pii]
AID - 10.1016/j.archger.2018.11.006 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2019 Mar-Apr;81:1-7. doi: 10.1016/j.archger.2018.11.006. 
      Epub 2018 Nov 13.