PMID- 30471376
OWN - NLM
STAT- MEDLINE
DCOM- 20190410
LR  - 20190410
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 555
DP  - 2019 Jan 30
TI  - Fabrication of the polyphosphates patched cellulose sulfate-chitosan 
      hydrochloride microcapsules and as vehicles for sustained drug release.
PG  - 291-302
LID - S0378-5173(18)30881-0 [pii]
LID - 10.1016/j.ijpharm.2018.11.058 [doi]
AB  - Polyphosphates are important polyanionic electrolytes that play a major role in 
      stabilization and consolidation of colloids surface and interior microstructures. 
      In this study, the polyelectrolyte complexes (PEC) microcapsules (sodium 
      cellulose sulfate-chitosan hydrochloride, sample 1), and the patched ones via 
      sodium tripolyphosphate (sample 2), sodium pyrophosphate (sample 3) and sodium 
      hexametaphosphate (sample 4) were fabricated under mild conditions. The effects 
      of polyphosphates on the formation of the PEC microcapsules were investigated 
      systematically. Scanning electron microscope (SEM) and confocal laser scanning 
      microscope (CLSM) observation showed that both of the sample 2 and sample 3 had 
      more compact interior microstructures with higher fluorescence intensity, 
      compared with the sample 4 with macroporous ones and sample 1 with irregular 
      ones. Fourier transform-infrared spectroscopy (FT-IR) and thermogravimetric 
      analysis (TGA) showed the electrostatic interactions occurred among the -NH(3)(+) 
      groups, -SO(3)(-) groups, HP(3)O(10)(4-) groups, P(2)O(7)(4-) groups and 
      H(2)PO(4)(-) groups, and the sample 2 and sample 3 had a more thermal stability 
      comparatively. The sample microcapsules showed good capacity of drug loading and 
      encapsulation efficiency (max. 66.9 +/- 4.6% and 74.2 +/- 5.1%). In the in vitro 
      release studies showed that the sample 2 and sample 3 had a larger accumulative 
      drug release rate of 5-aminosalicylic acid (5-ASA) at the same time point and 
      released completely at 12 h; the drug release mechanisms analysis indicated that 
      the sample 1 and sample 3 were mainly diffusion controlled, while the sample 2 
      and sample 4 were followed the mechanism of non-Fickian transport. Under the 
      polyphosphate's consolidation, the PEC microcapsules fabricated with sustained 
      drug release profiles could be used as the promising drug vehicles.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Su, Ting
AU  - Su T
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Key 
      Laboratory of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, 
      Anhui, China.
FAU - Wu, Qing-Xi
AU  - Wu QX
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Anhui Key 
      Laboratory of Modern Biomanufacturing, Hefei 230601, Anhui, China; Key Laboratory 
      of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, Anhui, 
      China. Electronic address: wuqx@ahu.edu.cn.
FAU - Chen, Yan
AU  - Chen Y
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Anhui Key 
      Laboratory of Modern Biomanufacturing, Hefei 230601, Anhui, China; Key Laboratory 
      of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, Anhui, 
      China.
FAU - Zhao, Jin
AU  - Zhao J
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Key 
      Laboratory of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, 
      Anhui, China.
FAU - Cheng, Xiao-Du
AU  - Cheng XD
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Key 
      Laboratory of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, 
      Anhui, China.
FAU - Chen, Juan
AU  - Chen J
AD  - School of Life Sciences, Anhui University, Hefei 230601, Anhui, China; Key 
      Laboratory of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, 
      Anhui, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20181122
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Capsules)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Excipients)
RN  - 0 (Polyphosphates)
RN  - 4Q81I59GXC (Mesalamine)
RN  - 9004-34-6 (Cellulose)
RN  - 9012-76-4 (Chitosan)
RN  - 9032-43-3 (cellulose sulfate)
SB  - IM
MH  - Capsules
MH  - Cellulose/*analogs & derivatives/chemistry
MH  - Chemistry, Pharmaceutical/methods
MH  - Chitosan/*chemistry
MH  - Delayed-Action Preparations
MH  - Drug Liberation
MH  - Excipients/chemistry
MH  - Mesalamine/*administration & dosage/chemistry
MH  - Microscopy, Confocal
MH  - Microscopy, Electron, Scanning
MH  - Polyphosphates/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Thermogravimetry
MH  - Time Factors
OTO - NOTNLM
OT  - Cellulose sulfate
OT  - Chitosan hydrochloride
OT  - Polyelectrolyte complexes microcapsules
OT  - Polyphosphates
OT  - Sustained drug release
EDAT- 2018/11/25 06:00
MHDA- 2019/04/11 06:00
CRDT- 2018/11/25 06:00
PHST- 2018/05/03 00:00 [received]
PHST- 2018/11/01 00:00 [revised]
PHST- 2018/11/20 00:00 [accepted]
PHST- 2018/11/25 06:00 [pubmed]
PHST- 2019/04/11 06:00 [medline]
PHST- 2018/11/25 06:00 [entrez]
AID - S0378-5173(18)30881-0 [pii]
AID - 10.1016/j.ijpharm.2018.11.058 [doi]
PST - ppublish
SO  - Int J Pharm. 2019 Jan 30;555:291-302. doi: 10.1016/j.ijpharm.2018.11.058. Epub 
      2018 Nov 22.