PMID- 30471757
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1529-1774 (Electronic)
IS  - 1087-0024 (Linking)
VI  - 19
IP  - 2
DP  - 2018 Dec
TI  - Major Histocompatibility Complex and Psoriasis.
PG  - S79-S80
LID - S1087-0024(18)30006-6 [pii]
LID - 10.1016/j.jisp.2018.09.006 [doi]
AB  - Major histocompatibility complex (MHC), also known as human leukocyte antigen 
      (HLA) in humans, is one of the most genetically diverse regions in the genome of 
      various species. The human MHC contains about 400 genes in a  approximately 7.6-Mb span located 
      on the short arm of the chromosomal region 6p21.3. According to the NHGRI-EBI 
      Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/) 
      in HLA region, more than 500 associations have been identified for about 200 
      traits or phenotypes, including primary immune deficiencies, autoimmune diseases, 
      susceptibility to infections, malignancies, and psychiatric conditions (Welter 
      et al., 2014). For example, multiple sclerosis is associated with HLA-DRB1 *1501 
      (Handunnetthi et al., 2010); the control of HIV viral load is associated with 
      variants near HLA-C (Kulpa and Collins, 2011). Some acute drug reactions are 
      associated with specific HLA alleles. Carbamazepine-induced Stevens-Johnson 
      syndrome and toxic epidermal necrolysis have been strongly associated with 
      HLA-B*1502 in Han Chinese population and HLA-A*3101 in European populations 
      (Chung et al., 2004; McCormack et al., 2011). The HLA-B*13:01 is associated with 
      the development of the dapsone hypersensitivity syndrome among patients with 
      leprosy (Zhang et al., 2013).
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhou, Fusheng
AU  - Zhou F
AD  - The Institute of Dermatology and Department of Dermatology, First Affiliated 
      Hospital, Anhui Medical University, Hefei City, China.
FAU - Zhang, Xuejun
AU  - Zhang X
AD  - The Institute of Dermatology and Department of Dermatology, First Affiliated 
      Hospital, Anhui Medical University, Hefei City, China. Electronic address: 
      ayzxj@vip.sina.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Investig Dermatol Symp Proc
JT  - The journal of investigative dermatology. Symposium proceedings
JID - 9609059
EDAT- 2018/11/26 06:00
MHDA- 2018/11/26 06:01
CRDT- 2018/11/26 06:00
PHST- 2018/11/26 06:00 [entrez]
PHST- 2018/11/26 06:00 [pubmed]
PHST- 2018/11/26 06:01 [medline]
AID - S1087-0024(18)30006-6 [pii]
AID - 10.1016/j.jisp.2018.09.006 [doi]
PST - ppublish
SO  - J Investig Dermatol Symp Proc. 2018 Dec;19(2):S79-S80. doi: 
      10.1016/j.jisp.2018.09.006.