PMID- 30472199
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20200413
IS  - 2589-0409 (Electronic)
IS  - 1110-0362 (Linking)
VI  - 30
IP  - 4
DP  - 2018 Dec
TI  - The prognostic impact of loss of chromosome 7 material detected by fluorescence 
      in situ hybridization (FISH) in myeloid malignancies.
PG  - 133-138
LID - S1110-0362(18)30064-5 [pii]
LID - 10.1016/j.jnci.2018.11.001 [doi]
AB  - BACKGROUND: Monosomy 7 (-7) or deletion in its long arm [del(7q)] is among the 
      most common chromosomal abnormalities in myeloid malignancies. There are 
      prognostic variations between -7 and del(7q) in acute myeloid leukemia (AML) and 
      myelodysplastic syndrome (MDS). AIM: To describe the clinical characteristics, 
      response to treatment, and survival of patients with primary AML and MDS having 
      -7 or del(7q) detected by fluorescence in situ hybridization (FISH). PATIENTS AND 
      METHODS: The study was conducted on 53 patients with primary AML and MDS. They 
      were tested for chromosome 7 abnormality using FISH technique. RESULTS: 
      Thirty-one patients had chromosome 7 abnormality and 22 did not. Lower complete 
      remission and higher death rates were observed in patients with -7 (47.6% and 
      62%, respectively) when compared to patients with del(7q) (70% and 40%, 
      respectively) with no significant difference (p = 0.218 and 0.101, respectively). 
      The median overall survival (OS) of patients with -7, del(7q) and normal 
      chromosome 7 were 32.0, 43.0 and 50.0 months, respectively, with significant 
      statistical difference (p = 0.001). This difference was evident between patients 
      with -7 and those with normal chromosome 7 (p = 0.001), and less evident between 
      patients with -7 and those with del(7q) (p = 0.021). CONCLUSION: Chromosome 7 
      analysis has clear impact on the outcome of myeloid malignancies. The prognostic 
      variations between -7 and del(7q) is attributed to multiple factors. Cases with 
      del(7q) have better outcome than cases with -7. FISH provides a powerful tool for 
      detecting and monitoring patients with chromosome 7 abnormalities.
CI  - Copyright (c) 2018 National Cancer Institute, Cairo University. Production and 
      hosting by Elsevier B.V. All rights reserved.
FAU - El-Menoufy, Mohamed Amr M
AU  - El-Menoufy MAM
AD  - Hematology Department, Medical Research Institute, Alexandria University, 
      Alexandria, Egypt. Electronic address: mscfoh@yahoo.com.
FAU - Mourad, Zeinab I
AU  - Mourad ZI
AD  - Clinical Pathology Department, Faculty of Medicine, Alexandria University, 
      Alexandria, Egypt.
FAU - Farahat, Nahla M
AU  - Farahat NM
AD  - Clinical Pathology Department, Faculty of Medicine, Alexandria University, 
      Alexandria, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20181122
PL  - England
TA  - J Egypt Natl Canc Inst
JT  - Journal of the Egyptian National Cancer Institute
JID - 9424566
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Egypt
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/genetics/mortality/*physiopathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/genetics/mortality/*physiopathology/therapy
MH  - Prognosis
MH  - Survival Rate
MH  - Young Adult
OTO - NOTNLM
OT  - Chromosome 7
OT  - FISH
OT  - Monosomy 7
OT  - Myeloid malignancies
OT  - del(7q)
EDAT- 2018/11/26 06:00
MHDA- 2019/03/14 06:00
CRDT- 2018/11/26 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/11/03 00:00 [revised]
PHST- 2018/11/08 00:00 [accepted]
PHST- 2018/11/26 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2018/11/26 06:00 [entrez]
AID - S1110-0362(18)30064-5 [pii]
AID - 10.1016/j.jnci.2018.11.001 [doi]
PST - ppublish
SO  - J Egypt Natl Canc Inst. 2018 Dec;30(4):133-138. doi: 10.1016/j.jnci.2018.11.001. 
      Epub 2018 Nov 22.