PMID- 30473631
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1476-7961 (Print)
IS  - 1476-7961 (Electronic)
IS  - 1476-7961 (Linking)
VI  - 16
DP  - 2018
TI  - Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric 
      patients: correlation with filaggrin, eosinophil major basic protein and 
      immunoglobulin E.
PG  - 23
LID - 10.1186/s12948-018-0102-y [doi]
LID - 23
AB  - BACKGROUND: Allergic reactions have been implicated as contributions in a number 
      of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and 
      bronchial asthma (BA). However, the potential for filaggrin protein, eosinophil 
      major basic protein (MBP) and immunoglobulin E (IgE) to elicit allergic response 
      or to contribute to atopic disorders remains largely unexplored in pediatric 
      patients. This study was undertaken to investigate the status and contribution of 
      filaggrin protein, eosinophil MBP and total IgE in pediatric patients with AD, AR 
      and BA. METHODS: Sera from 395 pediatric patients of AD, AR or BA with varying 
      levels of disease activity according to the disease activity index and 410 
      age-matched non-atopic healthy controls were evaluated for serum levels of atopic 
      markers, including filaggrin, eosinophil MBP and IgE. RESULTS: Serum analysis 
      showed that filaggrin levels were remarkably high in pediatric patients with AD, 
      followed by BA and AR, whereas its levels were low in non-atopic pediatric 
      controls. Eosinophil MBP levels in sera of atopic patients were significantly 
      high as compared with their respective controls, but its levels were highest in 
      AR patients, followed by AD and BA. Total IgE in sera of AD patients was markedly 
      high, followed by AR and BA patients, whereas its levels were low in non-atopic 
      pediatric controls. Interestingly, not only was an increased number of subjects 
      positive for filaggrin protein, eosinophil MBP or total IgE, but also their 
      levels were statistically significantly higher among those atopic patients whose 
      disease activity scores were higher as compared with atopic patients with lower 
      disease activity scores. CONCLUSIONS: These findings strongly support a role of 
      filaggrin protein, eosinophil MBP and IgE in the onset of allergic reactions in 
      pediatric patients with AD, AR and BA. The data suggest that filaggrin, 
      eosinophil MBP or IgE might be useful in evaluating the progression of AD, AR or 
      BA and in elucidating the mechanisms involved in the pathogenesis of these 
      pediatric disorders.
FAU - Rasheed, Zafar
AU  - Rasheed Z
AUID- ORCID: 0000-0002-8651-4218
AD  - 1Department of Medical Biochemistry, College of Medicine, Qassim University, P.O. 
      Box 6655, Buraidah, 51452 Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: 
      grid.412602.3
FAU - Zedan, Khaled
AU  - Zedan K
AD  - 2Department of Pediatrics, College of Medicine, Qassim University, Buraidah, 
      Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
FAU - Saif, Ghada Bin
AU  - Saif GB
AD  - 3Department of Dermatology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia. ISNI: 0000 0004 1773 5396. GRID: grid.56302.32
FAU - Salama, Ragaa H
AU  - Salama RH
AD  - 1Department of Medical Biochemistry, College of Medicine, Qassim University, P.O. 
      Box 6655, Buraidah, 51452 Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: 
      grid.412602.3
FAU - Salem, Tarek
AU  - Salem T
AD  - 1Department of Medical Biochemistry, College of Medicine, Qassim University, P.O. 
      Box 6655, Buraidah, 51452 Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: 
      grid.412602.3
FAU - Ahmed, Ahmed A
AU  - Ahmed AA
AD  - 4Research Center, College of Medicine, Qassim University, Buraidah, Saudi Arabia. 
      ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
FAU - El-Moniem, Alaa Abd
AU  - El-Moniem AA
AD  - 5Department of Medicine, College of Medicine, Qassim University, Buraidah, Saudi 
      Arabia. ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
FAU - Elkholy, Maha
AU  - Elkholy M
AD  - 5Department of Medicine, College of Medicine, Qassim University, Buraidah, Saudi 
      Arabia. ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
FAU - Al Robaee, Ahmad A
AU  - Al Robaee AA
AD  - 6Department of Dermatology, College of Medicine, Qassim University, Buraidah, 
      Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
FAU - Alzolibani, Abdullateef A
AU  - Alzolibani AA
AD  - 6Department of Dermatology, College of Medicine, Qassim University, Buraidah, 
      Saudi Arabia. ISNI: 0000 0000 9421 8094. GRID: grid.412602.3
LA  - eng
PT  - Journal Article
DEP - 20181112
PL  - England
TA  - Clin Mol Allergy
JT  - Clinical and molecular allergy : CMA
JID - 101152195
PMC - PMC6233599
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Atopic dermatitis
OT  - Atopic disorders
OT  - Bronchial asthma
OT  - Eosinophil MBP
OT  - Filaggrin
OT  - IgE
OT  - Pediatric patients
EDAT- 2018/11/27 06:00
MHDA- 2018/11/27 06:01
PMCR- 2018/11/12
CRDT- 2018/11/27 06:00
PHST- 2018/09/16 00:00 [received]
PHST- 2018/11/03 00:00 [accepted]
PHST- 2018/11/27 06:00 [entrez]
PHST- 2018/11/27 06:00 [pubmed]
PHST- 2018/11/27 06:01 [medline]
PHST- 2018/11/12 00:00 [pmc-release]
AID - 102 [pii]
AID - 10.1186/s12948-018-0102-y [doi]
PST - epublish
SO  - Clin Mol Allergy. 2018 Nov 12;16:23. doi: 10.1186/s12948-018-0102-y. eCollection 
      2018.