PMID- 30477827
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 41
DP  - 2018 Dec
TI  - The effects of Zataria multiflora Boiss. (Shirazi thyme) on nonalcoholic fatty 
      liver disease and insulin resistance: A randomized double-blind 
      placebo-controlled clinical trial.
PG  - 118-123
LID - S0965-2299(18)30712-X [pii]
LID - 10.1016/j.ctim.2018.09.010 [doi]
AB  - OBJECTIVE: The aim of the study is to evaluate the effects of Zataria multiflora 
      Boiss. (Shirazi thyme) (ZM) supplementation on nonalcoholic fatty liver disease 
      (NAFLD) and related insulin resistance (IR). DESIGN: In this randomized 
      double-blind placebo-controlled clinical trial, 85 patients with NAFLD were 
      administered either 700 mg ZM powder or placebo twice daily for 12 weeks. All 
      patients were advised to follow the recommendations for diet modification. 
      RESULTS: ZM supplementation resulted in a significant reduction in serum insulin 
      level (-2.72 +/- 0.80 vs -0.67 +/- 0.90, P(=)0.030), insulin resistance (-0.80 +/- 0.22 
      vs 0.06 +/- 0.22, P(=)0.023), systolic (-3.44 +/- 1.05 vs 1.03 +/- 0.98, P(=) 0.002) 
      and diastolic (-2.33 +/- 0.77 vs 0.26 +/- 0.63, P(=) 0.009) blood pressure in 
      patients with NAFLD in comparison with the placebo group. There was no 
      significant difference between two groups regarding serum levels of alanine 
      aminotransferase (ALT), high sensitive C-reactive protein (hs-CRP), Tumor 
      necrosis factor-alpha (TNF-alpha), grade of fatty liver in ultrasonography, lipid 
      profiles, and other outcomes. CONCLUSION: ZM supplementation with daily dose of 
      1400 mg for 12 weeks improved insulin resistance in patients with NAFLD. Further 
      studies with longer duration and larger sample size are recommended.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Zamani, Nasrindokht
AU  - Zamani N
AD  - Research Center for Persian Medicine and History of Medicine, Shiraz University 
      of Medical Sciences, Shiraz, Iran.
FAU - Shams, Mesbah
AU  - Shams M
AD  - Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, 
      Shiraz, Iran. Electronic address: shams@sums.ac.ir.
FAU - Nimrouzi, Majid
AU  - Nimrouzi M
AD  - Department of Persian Medicine, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran. Electronic address: mnimruzi@yahoo.com.
FAU - Zarshenas, Mohammad Mehdi
AU  - Zarshenas MM
AD  - Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz 
      University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals 
      (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Abolhasani Foroughi, Amin
AU  - Abolhasani Foroughi A
AD  - Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
FAU - Fallahzadeh Abarghooei, Ebrahim
AU  - Fallahzadeh Abarghooei E
AD  - Department of Persian Medicine, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Fattahi, Mohammad Reza
AU  - Fattahi MR
AD  - Gasteroenterohepatology Research Center, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180917
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Plant Extracts)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
CIN - Complement Ther Med. 2019 Feb;42:270. PMID: 30670253
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Blood Pressure/drug effects
MH  - C-Reactive Protein/metabolism
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - Lipids/blood
MH  - Liver/*drug effects/pathology
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/blood/*drug therapy
MH  - *Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - *Thymus Plant
OTO - NOTNLM
OT  - Dietary supplements
OT  - Herbal medicine
OT  - Insulin resistance
OT  - Nonalcoholic fatty liver disease
OT  - Thymus plant
OT  - Traditional medicine
OT  - Zataria multiflora
EDAT- 2018/11/28 06:00
MHDA- 2019/03/05 06:00
CRDT- 2018/11/28 06:00
PHST- 2018/07/20 00:00 [received]
PHST- 2018/09/13 00:00 [revised]
PHST- 2018/09/14 00:00 [accepted]
PHST- 2018/11/28 06:00 [entrez]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
AID - S0965-2299(18)30712-X [pii]
AID - 10.1016/j.ctim.2018.09.010 [doi]
PST - ppublish
SO  - Complement Ther Med. 2018 Dec;41:118-123. doi: 10.1016/j.ctim.2018.09.010. Epub 
      2018 Sep 17.