PMID- 30477846
OWN - NLM
STAT- MEDLINE
DCOM- 20190308
LR  - 20190308
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 41
DP  - 2018 Dec
TI  - Hypnotherapy for insomnia: A randomized controlled trial comparing generic and 
      disease-specific suggestions.
PG  - 231-239
LID - S0965-2299(18)30618-6 [pii]
LID - 10.1016/j.ctim.2018.10.008 [doi]
AB  - STUDY OBJECTIVES: Hypnotherapy is commonly used for treating insomnia, but a 
      definite conclusion regarding its safety and effectiveness is unavailable due to 
      a lack of adverse event monitoring and comparison between generic and 
      disease-specific hypnotic suggestions in previous studies. DESIGN: Randomized 
      controlled, participant-blind, parallel-group with subject recruitment after 
      trial registry. INTERVENTIONS: Sixty participants were randomized to receive 
      4-week once-weekly 1-hour hypnotherapy with disease-specific suggestions (using 
      counter-hyperarousal hypnotic exercise and screen visualization technique 
      targeted at insomnia-related anxieties) or generic suggestions (using thought 
      distraction technique and suggestions for self-confidence and self-care 
      enhancement). MAIN OUTCOME MEASURES: Primary outcome was sleep efficiency (SE) 
      derived from 1-week sleep diary at weeks 4, 6 and 9. Secondary outcomes included 
      other sleep-diary parameters, Insomnia Severity Index, Hospital Anxiety and 
      Depression Scale, and Sheehan Disability Index. Treatment expectancy, adverse 
      events (AEs), and subjective experiences were obtained after hypnotherapy 
      sessions 2 and 4. RESULTS: Mixed linear modeling showed that time effect was 
      significant for most variables. Within-group effect size of sleep-diary-derived 
      SE from baseline to follow-up ranged from 0.70 to 0.90 for disease-specific 
      suggestions (mean difference: 8.5-10.4%); for generic suggestions, it was 
      0.65-0.69 (mean difference: 6.8-8.3%); however, no significant between-group 
      difference was found. Discontinuation rate was 10%, report of unpleasantness 
      varied from 5.5 to 7.4%, while the incidence of AEs ranged from 37.0 to 51.8%, 
      depending on session content. CONCLUSION: Hypnotherapy using disease-specific and 
      generic suggestions produced similar improvements in sleep and daytime 
      functioning. AEs were common but mostly mild. The finding raises doubts about the 
      value of disease-specific suggestions in hypnotherapy for insomnia. TRIAL 
      REGISTRATION: This clinical trial was registered on 23 May 2014 at the University 
      of Hong Kong Clinical Trials Registry as "Hypnotherapy for insomnia: a randomized 
      placebo-controlled trial" (HKUCTR-1874).
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Lam, Tak-Ho
AU  - Lam TH
AD  - Department of Psychiatry, University of Hong Kong, Hong Kong Special 
      Administrative Region.
FAU - Chung, Ka-Fai
AU  - Chung KF
AD  - Department of Psychiatry, University of Hong Kong, Hong Kong Special 
      Administrative Region. Electronic address: kfchung@hku.hk.
FAU - Lee, Chit-Tat
AU  - Lee CT
AD  - Department of Psychiatry, Queen Mary Hospital, Hong Kong Special Administrative 
      Region.
FAU - Yeung, Wing-Fai
AU  - Yeung WF
AD  - School of Nursing, Hong Kong Polytechnic University, Hong Kong Special 
      Administrative Region.
FAU - Yu, Branda Yee-Man
AU  - Yu BY
AD  - School of Nursing, Hong Kong Polytechnic University, Hong Kong Special 
      Administrative Region.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181009
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - China
MH  - Female
MH  - Humans
MH  - *Hypnosis
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Sleep Initiation and Maintenance Disorders/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Disease-specific suggestions
OT  - Generic suggestions
OT  - Hypnosis
OT  - Hypnotherapy
OT  - Insomnia
OT  - Randomized controlled trial
OT  - Sleep
EDAT- 2018/11/28 06:00
MHDA- 2019/03/09 06:00
CRDT- 2018/11/28 06:00
PHST- 2018/06/28 00:00 [received]
PHST- 2018/09/07 00:00 [revised]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/11/28 06:00 [entrez]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2019/03/09 06:00 [medline]
AID - S0965-2299(18)30618-6 [pii]
AID - 10.1016/j.ctim.2018.10.008 [doi]
PST - ppublish
SO  - Complement Ther Med. 2018 Dec;41:231-239. doi: 10.1016/j.ctim.2018.10.008. Epub 
      2018 Oct 9.