PMID- 30478377
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20191217
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Nov 26
TI  - IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK 
      pathway.
PG  - 17347
LID - 10.1038/s41598-018-35485-2 [doi]
LID - 17347
AB  - Atherosclerosis is characterized as a chronic inflammatory disease and 
      macrophage-derived foam cells play a central role during the pathologic 
      processes. A newly discovered cytokine interleukin-34 (IL-34) is closely 
      associated with various inflammatory and autoimmune diseases. Expression of IL-34 
      in obesity, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), lupus 
      nephritis and coronary artery diseases (CAD) are significantly elevated. However, 
      the role of IL-34 in atherosclerosis remains unknown. In our present study, we 
      found that IL-34 treatment markedly increased the uptake of oxLDL, intracellular 
      total and esterified cholesterol content but not cholesterol efflux, subsequently 
      promoted foam cell formation through up-regulating CD36 expression via p38 MAPK 
      signal pathway in bone marrow derived macrophages (BMDMs). Furthermore, treatment 
      with IL-34 significantly elevated the oxLDL-induced up-regulation of 
      pro-inflammatory cytokines. Our results conclude that IL-34 facilitates foam cell 
      formation by increasing CD36-mediated lipid uptake and suggest a potential new 
      risk biomarker for atherosclerosis.
FAU - Liu, Qingyan
AU  - Liu Q
AD  - Comprehensive Liver Cancer Center, 302 Military Hospital of China, Beijing, 
      100039, China.
FAU - Fan, Jiao
AU  - Fan J
AD  - Institute of Geriatrics, National Clinical Research Center of Geriatrics Disease, 
      Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Bai, Jing
AU  - Bai J
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Peng, Liang
AU  - Peng L
AD  - Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, 450003, 
      China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Deng, Lei
AU  - Deng L
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Wang, Gaokun
AU  - Wang G
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Nong, Jingguo
AU  - Nong J
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
FAU - Zhang, Minghua
AU  - Zhang M
AD  - Clinical Pharmacy Laboratory, Chinese PLA General Hospital, Beijing, 100853, 
      China. zmreformer@126.com.
FAU - Wang, Yu
AU  - Wang Y
AD  - Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China. 
      wangyuheart@yeah.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181126
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (ABCA1 protein, mouse)
RN  - 0 (ABCG1 protein, mouse)
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (CD36 Antigens)
RN  - 0 (Interleukins)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (interleukin-34, mouse)
RN  - 0 (oxidized low density lipoprotein)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/metabolism
MH  - Animals
MH  - Atherosclerosis/metabolism/pathology
MH  - Bone Marrow Cells/cytology
MH  - CD36 Antigens/genetics/*metabolism
MH  - Cholesterol/metabolism
MH  - Foam Cells/*cytology/metabolism
MH  - Interleukins/*metabolism/pharmacology
MH  - Lipoproteins, LDL/metabolism
MH  - Macrophages/cytology/drug effects/*metabolism
MH  - Mice, Inbred C57BL
MH  - Scavenger Receptors, Class B/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
PMC - PMC6255782
COIS- The authors declare no competing interests.
EDAT- 2018/11/28 06:00
MHDA- 2019/12/18 06:00
PMCR- 2018/11/26
CRDT- 2018/11/28 06:00
PHST- 2018/04/03 00:00 [received]
PHST- 2018/11/01 00:00 [accepted]
PHST- 2018/11/28 06:00 [entrez]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/11/26 00:00 [pmc-release]
AID - 10.1038/s41598-018-35485-2 [pii]
AID - 35485 [pii]
AID - 10.1038/s41598-018-35485-2 [doi]
PST - epublish
SO  - Sci Rep. 2018 Nov 26;8(1):17347. doi: 10.1038/s41598-018-35485-2.