PMID- 30479082
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 11
IP  - 1
DP  - 2019 Jan
TI  - Mugwort Pollen-Related Food Allergy: Lipid Transfer Protein Sensitization and 
      Correlation With the Severity of Allergic Reactions in a Chinese Population.
PG  - 116-128
LID - 10.4168/aair.2019.11.1.116 [doi]
AB  - PURPOSE: Little is known about the importance of lipid transfer protein (LTP) 
      sensitization in China. In this study, we investigated the relationship between 
      LTP sensitization and the severity of clinical symptoms in a population of 
      patients with mugwort pollen-related food allergy. METHODS: Food-induced symptoms 
      were evaluated in 148 patients with mugwort pollen allergy by a standardized 
      questionnaire. Specific immunoglobulin E (IgE) to Art v 1, Art v 3, Pru p 3, Ara 
      h 9 and Cor a 8 were quantified by ImmunoCAP. Immunoblotting of peach extracts 
      were performed with sera from peach-allergic patients. RESULTS: In total, 72% 
      (107/148) of the study population experienced food allergy. Forty-eight percent 
      (51/107) of patients with mugwort pollen-related food allergy experienced at 
      least 1 episode of food-induced anaphylaxis. Food allergy correlated with IgE 
      reactivity to Art v 3, but not to Art v 1. Sensitization to Pru p 3, Ara h 9 or 
      Cor a 8 was prevalent (80%, 69 or 63%, respectively) among individuals with food 
      allergy. Food allergic patients with systemic reactions (SR) had higher values 
      for Pru p 3, Ara h 9 and Cor a 8 than patients with oral allergy syndrome (OAS). 
      Furthermore, the strong IgE reactivity detected in immunoblots of peach extracts 
      indicated that Pru p 3 was the major allergen and was more prevalent in patients 
      with SR than in patients with OAS (100% vs. 55%). CONCLUSIONS: LTPs are major 
      food allergens for mugwort pollen-related food allergy in China, and may 
      contribute to SR.
CI  - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Deng, Shan
AU  - Deng S
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
AD  - Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on 
      Allergic Diseases, Beijing, China.
FAU - Yin, Jia
AU  - Yin J
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
AD  - Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on 
      Allergic Diseases, Beijing, China. doctoryinjia@163.com.
LA  - eng
GR  - 2016-I2M-1-003/Chinese Academy of Medical Sciences/
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6267181
OTO - NOTNLM
OT  - Lipid transfer protein
OT  - food allergy
OT  - mugwort pollen allergy
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2018/11/28 06:00
MHDA- 2018/11/28 06:01
PMCR- 2019/01/01
CRDT- 2018/11/28 06:00
PHST- 2018/03/19 00:00 [received]
PHST- 2018/07/02 00:00 [revised]
PHST- 2018/07/04 00:00 [accepted]
PHST- 2018/11/28 06:00 [entrez]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2018/11/28 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 11.116 [pii]
AID - 10.4168/aair.2019.11.1.116 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2019 Jan;11(1):116-128. doi: 
      10.4168/aair.2019.11.1.116.