PMID- 30479084
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 11
IP  - 1
DP  - 2019 Jan
TI  - Pollen/Fruit Syndrome: Clinical Relevance of the Cypress Pollen Allergenic 
      Gibberellin-Regulated Protein.
PG  - 143-151
LID - 10.4168/aair.2019.11.1.143 [doi]
AB  - A pollen/food-associated syndrome (PFAS) has been described between peach and 
      cypress pollen. Cross-reactive allergens were characterized which belong to the 
      Gibberellin-regulated protein (GRP) family, BP14 in cypress pollen and Pru p 7 in 
      peach. GRP are small cationic protein with anti-microbial properties. A patient 
      suffering from a peach/cypress syndrome was explored clinically and biologically 
      using 2 types of immunoglobulin E (IgE) multiarray microchip, immunoblots and a 
      basophil activation test to assess the clinical relevance of various extracts and 
      purified allergens from fruits or cypress pollen. In addition to PR10 
      sensitization, the patient showed specific IgE to Pru p 7, BP14 and allergen from 
      pomegranate. These last 3 allergens and allergenic sources are able to induce ex 
      vivo basophil activation characterized by the monitoring of the expression of 
      CD63 and CD203c, both cell surface markers correlated with a basophil mediator 
      release. Up to 100% of cells expressed CD203c at 50 ng/mL of BP14 protein. In 
      contrast, snakin-1, a GRP from potato sharing 82% sequence identity with Pru p 7 
      did not activate patient's basophils. These results strongly suggest that, like 
      Pru p 7, BP14 is a clinically relevant allergenic GRP from pollen. Allergen 
      members of this newly described protein family are good candidates for PFAS where 
      no cross-reactive allergens have been characterized.
CI  - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Senechal, Helene
AU  - Senechal H
AD  - Department of Biochemistry, Armand Trousseau Children Hospital, APHP, A&E 
      Research Team, Paris, France.
FAU - Keykhosravi, Sanaz
AU  - Keykhosravi S
AD  - Department of Biochemistry, Armand Trousseau Children Hospital, APHP, A&E 
      Research Team, Paris, France.
AD  - Paris-Sud Analytical Chemistry Group, Paris-Sud University, Orsay, France.
FAU - Couderc, Remy
AU  - Couderc R
AD  - Department of Biochemistry, Armand Trousseau Children Hospital, APHP, Paris, 
      France.
FAU - Selva, Marie Ange
AU  - Selva MA
AD  - Department of Biochemistry, Armand Trousseau Children Hospital, APHP, Paris, 
      France.
FAU - Shahali, Youcef
AU  - Shahali Y
AUID- ORCID: 0000-0003-3188-4374
AD  - Razi Vaccine and Serum Research Institute, Agricultural Research, Education and 
      Extension Organization, Karaj, Iran.
FAU - Aizawa, Tomoyasu
AU  - Aizawa T
AUID- ORCID: 0000-0001-9134-7576
AD  - Global Institution for Collaborative Research and Education, Protein Science 
      Laboratory, Hokkaido University, Sapporo, Japan.
FAU - Busnel, Jean Marc
AU  - Busnel JM
AD  - Beckman Coulter, Life Sciences Research, Marseille, France.
FAU - Arif, Rihane
AU  - Arif R
AD  - Beckman Coulter, Life Sciences Research, Marseille, France.
FAU - Mercier, Inna
AU  - Mercier I
AD  - Department of Allergology, Pasteur Institute Medical Center, Paris, France.
FAU - Pham-Thi, Nhan
AU  - Pham-Thi N
AD  - Department of Allergology, Pasteur Institute Medical Center, Paris, France.
FAU - Charpin, Denis Andre
AU  - Charpin DA
AD  - Department of Pneumonology and Allergy, La Timone Hospital, APHM, Aix-Marseille 
      University, Marseille, France.
FAU - Poncet, Pascal
AU  - Poncet P
AUID- ORCID: 0000-0003-0757-5424
AD  - Department of Biochemistry, Armand Trousseau Children Hospital, APHP, A&E 
      Research Team, Paris, France.
AD  - Pasteur Institute, Center of Resources and Technological Research, Paris, France. 
      pascal.poncet@pasteur.fr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6267187
OTO - NOTNLM
OT  - Cypress
OT  - allergen
OT  - basophil
OT  - peach
OT  - pollen
OT  - pomegranate
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2018/11/28 06:00
MHDA- 2018/11/28 06:01
PMCR- 2019/01/01
CRDT- 2018/11/28 06:00
PHST- 2018/07/12 00:00 [received]
PHST- 2018/09/04 00:00 [revised]
PHST- 2018/09/05 00:00 [accepted]
PHST- 2018/11/28 06:00 [entrez]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2018/11/28 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 11.143 [pii]
AID - 10.4168/aair.2019.11.1.143 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2019 Jan;11(1):143-151. doi: 
      10.4168/aair.2019.11.1.143.