PMID- 30479183
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20190103
IS  - 1744-7607 (Electronic)
IS  - 1742-5255 (Linking)
VI  - 15
IP  - 1
DP  - 2019 Jan
TI  - Drug-drug interactions in patients receiving hematopoietic stem cell 
      transplantation.
PG  - 49-59
LID - 10.1080/17425255.2019.1552256 [doi]
AB  - Recipients of hematopoietic stem cell transplantation (HSCT) are exposed to 
      numerous drugs in both pre- and post-transplantation period, which creates an 
      opportunity for drug-drug interactions (DDIs); if clinically relevant DDIs 
      happen, the risk of adverse treatment outcomes is increased. Areas covered: This 
      review is focused on DDIs in recipients of HSCT that were observed and published 
      as clinical trials, case series or case reports. Relevant publications were found 
      by the systematic search of the following online databases: MEDLINE, SCOPUS, 
      EBSCO, and SCINDEX. Expert opinion: The most important DDIs involve cytostatic or 
      immunosuppressant drug on one side, and antimicrobial drugs on the other. The 
      majority of clinically relevant interactions have pharmacokinetic character, 
      involving drug metabolizing enzymes in the liver. Antifungal azoles inhibit 
      metabolism of many cytostatic and immunosuppressant drugs at cytochromes and 
      increase their plasma concentrations. Macrolide antibiotics and fluoroqunolones 
      should be avoided in HSCT recipients, as they have much larger potential for DDIs 
      than other antibiotic groups. HSCT recipients increasingly receive new 
      immunomodulating drugs, and further observational studies are needed to reveal 
      unsuspected DDIs with clinical relevance.
FAU - Pejcic, Ana
AU  - Pejcic A
AUID- ORCID: 0000-0003-1741-0025
AD  - a Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
FAU - Jankovic, Slobodan M
AU  - Jankovic SM
AUID- ORCID: 0000-0002-1519-8828
AD  - a Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
FAU - Opancina, Valentina
AU  - Opancina V
AD  - a Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
FAU - Babic, Goran
AU  - Babic G
AD  - a Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
FAU - Milosavljevic, Milos
AU  - Milosavljevic M
AD  - a Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181127
PL  - England
TA  - Expert Opin Drug Metab Toxicol
JT  - Expert opinion on drug metabolism & toxicology
JID - 101228422
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Anti-Infective Agents/administration & dosage/adverse effects
MH  - Antineoplastic Agents/administration & dosage/adverse effects
MH  - *Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/adverse effects
OTO - NOTNLM
OT  - Drug-drug interactions
OT  - cytostatic drugs
OT  - hematopoietic stem cell transplantation
OT  - immunosuppressant drugs
OT  - prevention
EDAT- 2018/11/28 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/11/28 06:00
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2018/11/28 06:00 [entrez]
AID - 10.1080/17425255.2019.1552256 [doi]
PST - ppublish
SO  - Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):49-59. doi: 
      10.1080/17425255.2019.1552256. Epub 2018 Nov 27.