PMID- 30480468
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 29
IP  - 3
DP  - 2019 Mar
TI  - Incense smoke exposure augments systemic oxidative stress, inflammation and 
      endothelial dysfunction in male albino rats.
PG  - 211-218
LID - 10.1080/15376516.2018.1544681 [doi]
AB  - Incense smoke is reported to increase cardiovascular disease (CVD) risk in 
      exposed individuals. However, the mechanism underlying the toxic effect of 
      incense smoke on cardiovascular system is unclear. To test this, we chronically 
      exposed male albino rats to two different types of Arabian incense smoke and 
      studied their effects on oxidative stress, inflammation, and endothelial 
      function. Rats exposed to either of incense smoke showed a significant increase 
      in malondialdehyde (MDA) and a significant decline in superoxide dismutase (SOD) 
      and reduced glutathione (GSH). Endothelial functional marker, nitric oxide (NO) 
      was significantly decreased while endothelin-1 was significantly increased in 
      rats exposed to both the incense types. Incense smoke exposure also led to a 
      significant increase in chemokines and inflammatory mediators including monocyte 
      chemoattractant protein-1 (MCP-1), granulocyte-macrophage-colony stimulating 
      factor (GM-CSF), regulated on activation normal T cell expressed and secreted 
      (RANTES), interleukin-4 (IL-4), C-reactive protein (CRP), and tumor necrosis 
      factor-alpha (TNF-alpha). Besides, incense smoke-exposed rats demonstrated a 
      significant increase in the expression of intercellular adhesion molecule-1 
      (ICAM-1), vascular cell adhesion molecules-1 (VCAM-1), and E-selectin. 
      Importantly, cessation of incense smoke exposure for 30 days led to a significant 
      reversal in the levels of all the studied markers. Collectively, this study 
      describes oxidative stress, endothelial dysfunction, and inflammation as possible 
      underlying mechanisms in the toxic effects of incense smoke on increased CVD risk 
      in exposed individuals. Findings also underscore that avoiding incense smoke 
      exposure may have beneficial health effects.
FAU - Hussain, Tajamul
AU  - Hussain T
AD  - a Center of Excellence in Biotechnology Research, College of Science , King Saud 
      University , Riyadh , Saudi Arabia.
FAU - Alamery, Salman
AU  - Alamery S
AD  - a Center of Excellence in Biotechnology Research, College of Science , King Saud 
      University , Riyadh , Saudi Arabia.
AD  - b Biochemistry Department, College of Science , King Saud University , Riyadh , 
      Saudi Arabia.
FAU - Dikshit, Gambhir
AU  - Dikshit G
AD  - a Center of Excellence in Biotechnology Research, College of Science , King Saud 
      University , Riyadh , Saudi Arabia.
FAU - Mohammed, Arif A
AU  - Mohammed AA
AD  - a Center of Excellence in Biotechnology Research, College of Science , King Saud 
      University , Riyadh , Saudi Arabia.
FAU - Naushad, Shaik M
AU  - Naushad SM
AD  - c Biochemical Genetics, Sandor Life Sciences Pvt. Ltd , Hyderabad , India.
FAU - Alrokayan, Salman
AU  - Alrokayan S
AD  - b Biochemistry Department, College of Science , King Saud University , Riyadh , 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190116
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Endothelin-1)
RN  - 0 (Smoke)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Aorta, Abdominal/*drug effects/immunology/metabolism
MH  - Biomarkers/blood
MH  - Cell Adhesion Molecules/genetics
MH  - Cytokines/*blood
MH  - Endothelin-1/metabolism
MH  - Endothelium, Vascular/*drug effects/immunology/metabolism
MH  - Inhalation Exposure/*adverse effects
MH  - Male
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress/*drug effects/immunology
MH  - Rats, Wistar
MH  - Smoke/*adverse effects
OTO - NOTNLM
OT  - Incense
OT  - adhesion molecules
OT  - chemokines
OT  - endothelial dysfunction
OT  - inflammation
OT  - oxidative stress
EDAT- 2018/11/28 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/11/28 06:00
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/11/28 06:00 [entrez]
AID - 10.1080/15376516.2018.1544681 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2019 Mar;29(3):211-218. doi: 10.1080/15376516.2018.1544681. 
      Epub 2019 Jan 16.