PMID- 30482560
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20191025
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 74
IP  - 1
DP  - 2019 Jan
TI  - Evaluation of FDG PET combined with cardiac MRI for the diagnosis and therapeutic 
      monitoring of cardiac sarcoidosis.
PG  - 81.e9-81.e18
LID - S0009-9260(18)30552-X [pii]
LID - 10.1016/j.crad.2018.09.015 [doi]
AB  - AIM: To compare combined 2-[(18)F]-fluoro-2-deoxy-d-glucose 
      (FDG)-positron-emission tomography (PET) and cardiac magnetic resonance imaging 
      (CMR) for the diagnosis and therapy monitoring of cardiac sarcoidosis (CS). 
      MATERIALS AND METHODS: Eighty patients with sarcoidosis and a suspicion of CS who 
      underwent PET and CMR were included retrospectively. PET was undertaken after a 
      low-carbohydrate-high-fat diet in all patients using a combined 16-section 
      PET/computed tomography (CT) camera. PET was considered positive (PET+) in cases 
      of focal or multifocal FDG uptake. CMR was considered positive (CMR+) in cases of 
      subepicardial late gadolinium enhancement (LGE). A subgroup of 50 patients 
      (50/80) was monitored during therapy and classified as responders or 
      non-responders. RESULTS: Eighty-two percent of patients with PET+ (9/11) also had 
      CMR+ imaging, with good spatial agreement (kappa=0,79; 95% confidence interval 
      [CI]: 0.65-0.94). Twenty-seven percent (22/80) had residual physiological FDG 
      uptake, with a standardised uptake value (SUV) not significantly different 
      compared to the SUV from pathological uptake (6.4 versus 6 respectively, p=0,92). 
      The clinical response was more frequent in patients with baseline PET+ compared 
      to baseline PET- (80% versus 45%, p=0.07). PET findings improved in all cases 
      under treatment (7/7), whereas LGE improved in only 33% of patients (3/9). 
      CONCLUSION: Due to high risk of false-positive or undetermined findings, PET 
      might be performed as a second-line study in cases of LGE, to assess inflammatory 
      load. In addition, PET seems suitable to predict and assess response under 
      therapy.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Sgard, B
AU  - Sgard B
AD  - Department of Nuclear Medicine, Hopital Avicenne, Paris 13 University, Bobigny, 
      France.
FAU - Brillet, P-Y
AU  - Brillet PY
AD  - Department of Radiology, Hopital Avicenne, Paris 13 University, Bobigny, France.
FAU - Bouvry, D
AU  - Bouvry D
AD  - Department of Pneumology, Hopital Avicenne, Paris 13 University, Bobigny, France.
FAU - Djelbani, S
AU  - Djelbani S
AD  - Department of Nuclear Medicine, Hopital Avicenne, Paris 13 University, Bobigny, 
      France.
FAU - Nunes, H
AU  - Nunes H
AD  - Department of Pneumology, Hopital Avicenne, Paris 13 University, Bobigny, France.
FAU - Meune, C
AU  - Meune C
AD  - Department of Cardiology, Hopital Avicenne, Paris 13 University, Bobigny, France.
FAU - Valeyre, D
AU  - Valeyre D
AD  - Department of Pneumology, Hopital Avicenne, Paris 13 University, Bobigny, France.
FAU - Soussan, M
AU  - Soussan M
AD  - Department of Nuclear Medicine, Hopital Avicenne, Paris 13 University, Bobigny, 
      France. Electronic address: michael.soussan@aphp.fr.
LA  - eng
PT  - Journal Article
DEP - 20181025
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathies/*diagnostic imaging/pathology
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - *Positron-Emission Tomography/methods
MH  - Sarcoidosis/*diagnostic imaging/pathology
MH  - Young Adult
EDAT- 2018/11/30 06:00
MHDA- 2019/10/28 06:00
CRDT- 2018/11/29 06:00
PHST- 2018/05/26 00:00 [received]
PHST- 2018/09/26 00:00 [accepted]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2018/11/29 06:00 [entrez]
AID - S0009-9260(18)30552-X [pii]
AID - 10.1016/j.crad.2018.09.015 [doi]
PST - ppublish
SO  - Clin Radiol. 2019 Jan;74(1):81.e9-81.e18. doi: 10.1016/j.crad.2018.09.015. Epub 
      2018 Oct 25.