PMID- 30483251
OWN - NLM
STAT- MEDLINE
DCOM- 20191003
LR  - 20201125
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Distinct Role of IL-27 in Immature and LPS-Induced Mature Dendritic Cell-Mediated 
      Development of CD4(+) CD127(+)3G11(+) Regulatory T Cell Subset.
PG  - 2562
LID - 10.3389/fimmu.2018.02562 [doi]
LID - 2562
AB  - Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory 
      responses and autoimmunity; however, the molecular mechanisms of IL-27 in 
      modulation of immune tolerance and autoimmunity have not been fully elucidated. 
      Dendritic cells (DCs) play a central role in regulating immune responses mediated 
      by innate and adaptive immune systems, but regulatory mechanisms of DCs in CD4(+) 
      T cell-mediated immune responses have not yet been elucidated. Here we show that 
      IL-27 treated mature DCs induced by LPS inhibit immune tolerance mediated by 
      LPS-stimulated DCs. IL-27 treatment facilitates development of the CD4(+) 
      CD127(+)3G11(+) regulatory T cell subset in vitro and in vivo. By contrast, IL-27 
      treated immature DCs fail to modulate development of the CD4(+)CD127(+)3G11(+) 
      regulatory T cell sub-population in vitro and in vivo. Our results suggest that 
      IL-27 may break immune tolerance induced by LPS-stimulated mature DCs through 
      modulating development of a specific CD4(+) regulatory T cell subset mediated by 
      3G11 and CD127. Our data reveal a new cellular regulatory mechanism of IL-27 that 
      targets DC-mediated immune responses in autoimmune diseases such as multiple 
      sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
FAU - Zhou, Fang
AU  - Zhou F
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United 
      States.
FAU - Zhang, Guang-Xian
AU  - Zhang GX
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United 
      States.
FAU - Rostami, Abdolmohamad
AU  - Rostami A
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United 
      States.
LA  - eng
GR  - R01 AI106026/AI/NIAID NIH HHS/United States
GR  - R01 AI124386/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20181113
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Antigens, Surface)
RN  - 0 (Il27 protein, mouse)
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
RN  - 0 (Interleukins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (antigen 3G11, mouse)
SB  - IM
MH  - Animals
MH  - Antigens, Surface/*immunology
MH  - Autoimmunity/immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Dendritic Cells/*immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology
MH  - Female
MH  - Immune Tolerance/immunology
MH  - Interleukin-7 Receptor alpha Subunit/*immunology
MH  - Interleukins/*immunology
MH  - Lipopolysaccharides/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Multiple Sclerosis/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
PMC - PMC6244609
OTO - NOTNLM
OT  - IL-27
OT  - dendritic cell
OT  - immune tolerance
OT  - immunotherapy
OT  - regulatory T cell
EDAT- 2018/11/30 06:00
MHDA- 2019/10/08 06:00
PMCR- 2018/01/01
CRDT- 2018/11/29 06:00
PHST- 2018/07/16 00:00 [received]
PHST- 2018/10/17 00:00 [accepted]
PHST- 2018/11/29 06:00 [entrez]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.02562 [doi]
PST - epublish
SO  - Front Immunol. 2018 Nov 13;9:2562. doi: 10.3389/fimmu.2018.02562. eCollection 
      2018.