PMID- 30483503
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 6
DP  - 2018
TI  - Emerging Roles of Cellular Metabolism in Regulating Dendritic Cell Subsets and 
      Function.
PG  - 152
LID - 10.3389/fcell.2018.00152 [doi]
LID - 152
AB  - Dendritic cells (DCs) are the bridge between innate and T cell-dependent adaptive 
      immunity and are promising therapeutic targets for cancer and immune-mediated 
      disorders. Upon stimulation by pathogen or danger-sensing receptors, DCs become 
      activated and poised to induce T cell priming. Recent studies have identified 
      critical roles of metabolic pathways, including glycolysis, oxidative 
      phosphorylation, and fatty acid metabolism, in orchestrating DC function. In this 
      review, we discuss the shared and distinct metabolic programs shaping the 
      functional specification of different DC subsets, including conventional DCs, 
      bone marrow-derived DCs, and plasmacytoid DCs. We also briefly discuss the 
      signaling networks that tune metabolic programs in DC subsets.
FAU - Du, Xingrong
AU  - Du X
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 
      United States.
FAU - Chapman, Nicole M
AU  - Chapman NM
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 
      United States.
FAU - Chi, Hongbo
AU  - Chi H
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 
      United States.
LA  - eng
GR  - R01 AI105887/AI/NIAID NIH HHS/United States
GR  - R01 CA176624/CA/NCI NIH HHS/United States
GR  - R01 CA221290/CA/NCI NIH HHS/United States
GR  - R01 AI101407/AI/NIAID NIH HHS/United States
GR  - R01 NS064599/NS/NINDS NIH HHS/United States
GR  - R37 AI105887/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20181113
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC6243939
OTO - NOTNLM
OT  - dendritic cell
OT  - fatty acid
OT  - glycolysis
OT  - metabolism
OT  - oxidative phosphorylation
EDAT- 2018/11/30 06:00
MHDA- 2018/11/30 06:01
PMCR- 2018/01/01
CRDT- 2018/11/29 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/10/22 00:00 [accepted]
PHST- 2018/11/29 06:00 [entrez]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2018/11/30 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2018.00152 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2018 Nov 13;6:152. doi: 10.3389/fcell.2018.00152. 
      eCollection 2018.