PMID- 30483978
OWN - NLM
STAT- MEDLINE
DCOM- 20190712
LR  - 20210109
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 38
IP  - 4
DP  - 2019 Apr
TI  - Incidence and risk factors of new-onset hypertrophic pachymeningitis in patients 
      with anti-neutrophil antibody-associated vasculitis: using logistic regression 
      and classification tree analysis.
PG  - 1039-1046
LID - 10.1007/s10067-018-4372-z [doi]
AB  - OBJECTIVES: Hypertrophic pachymeningitis (HP) is a rare complication in patients 
      with anti-neutrophil antibody-associated vasculitis (AAV); its clinical features, 
      incidence, and risk factors remain unknown. We aimed to clarify the prevalence, 
      clinical features, and factors associated with new-onset HP in patients with AAV. 
      METHOD: A retrospective cohort study involving 93 patients with AAV was 
      conducted. HP incidence between patients with granulomatosis with polyangiitis 
      (GPA) and those with microscopic polyangiitis (MPA) was compared to investigate 
      risk factors associated with HP. We performed only univariate analysis using 
      logistic regression and classification tree (CART) analysis due to the small 
      number of HP cases. RESULTS: Among the 93 patients (76 with MPA and 17 with GPA), 
      only 6 patients developed HP (1 with MPA, 5 with GPA) over an average observation 
      period of 4 years; all patients who developed HP were positive for 
      myeloperoxidase anti-neutrophil antibody. HP incidence was significantly higher 
      in patients with GPA than in those with MPA (60.2 versus 3.3 persons per 1000 
      person-years, respectively, P = 0.002). The univariate analysis revealed that 
      otitis media (P < 0.001) and sinusitis (P = 0.014) were associated with new-onset 
      HP. Univariate CART analysis grouped the patients into patients with HP who have 
      otitis media (33%) and patients with HP who have sinusitis (21%). The odds ratio 
      of otitis media adjusted by age and first diagnosis of AAV was 38.1 (95% 
      confidence interval, 3.08-331.4; P = 0.004). CONCLUSIONS: Although only in the 
      univariate analysis, otitis media was the most discriminating factor to predict 
      new-onset HP in patients with AAV.
FAU - Imafuku, Aya
AU  - Imafuku A
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Sawa, Naoki
AU  - Sawa N
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan. naokis@toranomon.gr.jp.
AD  - Okinaka Memorial Institute for Medical Research, Toranomon Hospital, 2-2-2, 
      Toranomon, Minatoku, 105-8470, Japan. naokis@toranomon.gr.jp.
FAU - Kawada, Masahiro
AU  - Kawada M
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Hiramatsu, Rikako
AU  - Hiramatsu R
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Hasegawa, Eiko
AU  - Hasegawa E
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Yamanouchi, Masayuki
AU  - Yamanouchi M
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Hoshino, Junichi
AU  - Hoshino J
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Ubara, Yoshihumi
AU  - Ubara Y
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
FAU - Takaichi, Kenmei
AU  - Takaichi K
AD  - Department of Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minatoku, 
      105-8470, Japan.
LA  - eng
PT  - Journal Article
DEP - 20181127
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Meningitis/*epidemiology
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Granulomatosis with polyangiitis
OT  - Hypertrophic pachymeningitis
OT  - Microscopic polyangiitis
OT  - Myeloperoxidase anti-neutrophil antibody
OT  - Otitis media
OT  - Proteinase 3 anti-neutrophil antibody
EDAT- 2018/11/30 06:00
MHDA- 2019/07/13 06:00
CRDT- 2018/11/29 06:00
PHST- 2018/09/28 00:00 [received]
PHST- 2018/11/14 00:00 [accepted]
PHST- 2018/11/11 00:00 [revised]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/07/13 06:00 [medline]
PHST- 2018/11/29 06:00 [entrez]
AID - 10.1007/s10067-018-4372-z [pii]
AID - 10.1007/s10067-018-4372-z [doi]
PST - ppublish
SO  - Clin Rheumatol. 2019 Apr;38(4):1039-1046. doi: 10.1007/s10067-018-4372-z. Epub 
      2018 Nov 27.