PMID- 30484122
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20200225
IS  - 1476-5535 (Electronic)
IS  - 1367-5435 (Linking)
VI  - 46
IP  - 3-4
DP  - 2019 Mar
TI  - Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in 
      the genomic era.
PG  - 459-468
LID - 10.1007/s10295-018-2092-7 [doi]
AB  - 2,2'-Bipyridine (2,2'-BP) is the unique molecular scaffold of the bioactive 
      natural products represented by caerulomycins (CAEs) and collismycins (COLs). 
      CAEs and COLs are highly similar in the chemical structures in which their 
      2,2'-BP cores typically contain a di- or tri-substituted ring A and an unmodified 
      ring B. Here, we summarize the CAE and COL-type 2,2'-BP natural products known or 
      hypothesized to date: (1) isolated using methods traditional for natural product 
      characterization, (2) created by engineering the biosynthetic pathways of CAEs or 
      COLs, and (3) predicted upon bioinformatics-guided genome mining. The 
      identification of these CAE and COL-type 2,2'-BP natural products not only 
      demonstrates the development of research techniques and methods in the field of 
      natural product chemistry but also reflects the general interest in the discovery 
      of CAE and COL-type 2,2'-BP natural products.
FAU - Chen, Dandan
AU  - Chen D
AD  - State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for 
      Excellence on Molecular Synthesis, Shanghai Institute of Organic Chemistry, 
      University of Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai, 
      China.
AD  - Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, 313000, Huzhou, 
      China.
FAU - Zhao, Qunfei
AU  - Zhao Q
AD  - Innovation Research Institute of Traditional Chinese Medicine, Shanghai 
      University of Traditional Chinese Medicine, 1200 Cailun Road, 201203, Shanghai, 
      China.
FAU - Liu, Wen
AU  - Liu W
AD  - State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for 
      Excellence on Molecular Synthesis, Shanghai Institute of Organic Chemistry, 
      University of Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai, 
      China. wliu@sioc.ac.cn.
AD  - Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, 313000, Huzhou, 
      China. wliu@sioc.ac.cn.
LA  - eng
GR  - 21472231/National Natural Science Foundation of China/
GR  - 21520102004/National Natural Science Foundation of China/
GR  - 31430005/National Natural Science Foundation of China/
GR  - 21750004/National Natural Science Foundation of China/
GR  - SQYZDJ-SSW-SLH1037/Chinese Academy of Sciences/
GR  - XDB20020200/Chinese Academy of Sciences/
GR  - 17JC1405100/Science and Technology Commission of Shanghai Municipality/
GR  - 15JC1400400/Science and Technology Commission of Shanghai Municipality/
GR  - 2018ZX09711001-006-010/National Mega-project for Innovative Drugs/
GR  - 2017303/Youth Innovation Promotion Association of the Chinese Academy of 
      Sciences/
PT  - Journal Article
PT  - Review
DEP - 20181127
PL  - Germany
TA  - J Ind Microbiol Biotechnol
JT  - Journal of industrial microbiology & biotechnology
JID - 9705544
RN  - 0 (Bacterial Proteins)
RN  - 0 (Biological Products)
RN  - 21802-37-9 (cerulomycin)
RN  - 551W113ZEP (2,2'-Dipyridyl)
SB  - IM
MH  - 2,2'-Dipyridyl/*analogs & derivatives/chemistry
MH  - Bacterial Proteins/genetics/metabolism
MH  - Biological Products/chemistry
MH  - Biosynthetic Pathways/genetics
MH  - Computational Biology
MH  - *Drug Discovery
MH  - *Genome, Bacterial
MH  - Genomics
MH  - Multigene Family
MH  - Streptomyces/genetics/metabolism
OTO - NOTNLM
OT  - 2,2'-Bipyridine
OT  - Caerulomycin
OT  - Collismycin
OT  - Natural product discovery
OT  - Natural products
EDAT- 2018/11/30 06:00
MHDA- 2019/05/08 06:00
CRDT- 2018/11/29 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2018/11/29 06:00 [entrez]
AID - 10.1007/s10295-018-2092-7 [pii]
AID - 10.1007/s10295-018-2092-7 [doi]
PST - ppublish
SO  - J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):459-468. doi: 
      10.1007/s10295-018-2092-7. Epub 2018 Nov 27.