PMID- 30484670
OWN - NLM
STAT- MEDLINE
DCOM- 20181231
LR  - 20191108
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 67
IP  - Suppl 3
DP  - 2018 Nov 28
TI  - Genetic predictors of the development and recurrence of Graves' disease.
PG  - S431-S439
AB  - Graves' disease affects approximately 3 % of women and 0.5 % of men. The 
      first-choice therapy is based on the administration of thyrostatic drugs. 
      However, approximately half of patients relapse within two years of 
      discontinuation. These patients must then decide whether to re-initiate 
      thyrostatics, which may have serious side effects, or to undergo surgery or 
      radioiodine treatment. Familial forms of Graves' disease indicate a significant 
      genetic component, with twin studies demonstrating a contribution of genetic 
      factors up to 70-80 %. The autoimmune nature of the disease involves the human 
      leukocyte antigen (HLA) complex, which has a decisive impact on each individual's 
      immune response. Within HLA, some variants of the DRB1, DQA1 and DQB1 genes 
      appear to be possible predictors of the development and recurrence of Graves' 
      disease. Outside the HLA region, many variants of immunocompetent genes have also 
      been identified as potential Graves' disease predictors. Apart from the immune 
      system, some thyroid-specific genes have been described in relation to the 
      disease. Here, we present current knowledge regarding the genetic components 
      involved in the development and recurrence of Graves' disease. Further, we 
      present original pilot results from a cohort of Czech Graves' disease patients 
      regarding the HLA variants.
FAU - Vejrazkova, D
AU  - Vejrazkova D
AD  - Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech 
      Republic. dvejrazkova@endo.cz.
FAU - Vcelak, J
AU  - Vcelak J
FAU - Vaclavikova, E
AU  - Vaclavikova E
FAU - Vankova, M
AU  - Vankova M
FAU - Zajickova, K
AU  - Zajickova K
FAU - Duskova, M
AU  - Duskova M
FAU - Vrbikova, J
AU  - Vrbikova J
FAU - Bendlova, B
AU  - Bendlova B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Cohort Studies
MH  - Czech Republic/epidemiology
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Graves Disease/*diagnosis/epidemiology/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Pilot Projects
MH  - Predictive Value of Tests
MH  - Recurrence
MH  - Thyroid Gland/pathology/physiology
EDAT- 2018/11/30 06:00
MHDA- 2019/01/01 06:00
CRDT- 2018/11/29 06:00
PHST- 2018/11/29 06:00 [entrez]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/01/01 06:00 [medline]
AID - 934018 [pii]
AID - 10.33549/physiolres.934018 [doi]
PST - ppublish
SO  - Physiol Res. 2018 Nov 28;67(Suppl 3):S431-S439. doi: 10.33549/physiolres.934018.