PMID- 30485513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230201
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 5
DP  - 2019 May
TI  - Long noncoding RNA LINC00339 promotes laryngeal squamous cell carcinoma cell 
      proliferation and invasion via sponging miR-145.
PG  - 8272-8279
LID - 10.1002/jcb.28110 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) is a very common neoplasm of the head 
      and neck in the world. Long noncoding RNAs play key roles in cell infiltration, 
      fate, apoptosis, and invasion. However, the functional role and expression of 
      LINC00339 remains unclear in LSCC. In this study, we showed that the expression 
      level of LINC00339 was upregulated in LSCC tissues and cell lines. LINC00339 
      silencing suppressed the proliferation, invasion, and epithelial-mesenchymal 
      transition (EMT) progression of LSCC cells. In addition, we showed that LINC00339 
      acted as a sponge of miR-145, and LINC00339 silencing promoted the expression of 
      miR-145 in Hep2 cell. Furthermore, the expression of miR-145 was lower in LSCC 
      tissues than in their paired normal samples and the miR-145 expression level was 
      negatively correlated with LINC00339 expression in LSCC tissues. The knockdown of 
      miR-145 promoted the proliferation, invasion, and EMT progression of LSCC cells. 
      Finally, we indicated that LINC00339 silencing inhibited the proliferation, 
      invasion, and EMT progression of LSCC cells by suppressing the miR-145 
      expression. These data suggested that LINC00339 acted as an oncogene in the 
      development of LSCC, partly by regulating the miR-145 expression.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Liu, Shouzhou
AU  - Liu S
AD  - Department of Otolaryngology, Liaocheng People's Hospital, Liaocheng, China.
FAU - Duan, Wenchao
AU  - Duan W
AUID- ORCID: 0000-0002-3117-6397
AD  - Department of Otolaryngology, Liaocheng People's Hospital, Liaocheng, China.
LA  - eng
PT  - Journal Article
DEP - 20181128
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
SB  - IM
OTO - NOTNLM
OT  - LINC00339
OT  - laryngeal squamous cell carcinoma
OT  - long noncoding RNAs
OT  - miR-145
EDAT- 2018/11/30 06:00
MHDA- 2018/11/30 06:01
CRDT- 2018/11/29 06:00
PHST- 2018/09/14 00:00 [received]
PHST- 2018/10/31 00:00 [accepted]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2018/11/30 06:01 [medline]
PHST- 2018/11/29 06:00 [entrez]
AID - 10.1002/jcb.28110 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 May;120(5):8272-8279. doi: 10.1002/jcb.28110. Epub 2018 Nov 
      28.