PMID- 30487812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 9
DP  - 2018
TI  - Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 
      Diabetes Mellitus Susceptibility: An Updated Meta-Analysis.
PG  - 541
LID - 10.3389/fgene.2018.00541 [doi]
LID - 541
AB  - Background: The Leu72Met polymorphism of ghrelin gene has been associated with 
      genetic predisposition to type 2 diabetes mellitus (T2DM), while conclusions 
      remain conflicting. Hence, we performed this updated meta-analysis to clarify the 
      association between Leu72Met polymorphism and T2DM susceptibility. Methods: Six 
      electronic databases were consulted for articles published before 1 January, 
      2018. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated 
      under five genetic models to assess this association. We used I (2)-test and Q 
      statistics to measure heterogeneity across the included studies. Subgroup 
      analyses and publication bias were also performed. Results: Thirteen case-control 
      studies involving 4720 T2DM patients and 4206 controls were included in this 
      meta-analysis. The overall results using fixed-effects models showed that 
      Leu72Met polymorphism was significantly associated with an increased risk of T2DM 
      under homozygous model (OR = 1.307, 95%CI 1.001-1.705, p = 0.049). Further 
      subgroup analyses stratified by ethnicity revealed that the risk for T2DM was 
      only increased in Asians (homozygous model: OR = 1.335, 95%CI 1.014-1.758, p = 
      0.040), while decreased in Caucasians (dominant model: OR = 0.788, 95%CI 
      0.635-0.978, p = 0.030; heterozygous model: OR = 0.779, 95%CI 0.626-0.969, p = 
      0.025; allelic model: OR = 0.811, 95%CI 0.661-0.995, p = 0.045). Funnel plots 
      were basically symmetrical, and all p-values of Egger's test under five genetic 
      models were >0.050, which indicated no evidence of publication bias. Conclusions: 
      Our results demonstrate that the Leu72Met polymorphism of ghrelin gene may be 
      protective against T2DM in Caucasians, while predisposing to T2DM in Asians.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - Medical School of Southeast University, Nanjing, China.
FAU - Tian, Sai
AU  - Tian S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
FAU - Sun, Jie
AU  - Sun J
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
FAU - Shen, Yanjue
AU  - Shen Y
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20181114
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6246653
OTO - NOTNLM
OT  - Leu72Met
OT  - ghrelin
OT  - meta-analysis
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2018/11/30 06:00
MHDA- 2018/11/30 06:01
PMCR- 2018/11/14
CRDT- 2018/11/30 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/10/26 00:00 [accepted]
PHST- 2018/11/30 06:00 [entrez]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2018/11/30 06:01 [medline]
PHST- 2018/11/14 00:00 [pmc-release]
AID - 10.3389/fgene.2018.00541 [doi]
PST - epublish
SO  - Front Genet. 2018 Nov 14;9:541. doi: 10.3389/fgene.2018.00541. eCollection 2018.